Background-—Renal impairment is a common comorbidity and the strongest risk factor for poor prognosis in acute decompensated heart failure (ADHF). In clinical practice, renal function is labile during episodes of ADHF, and often worsens after discharge. The significance of worsening of renal function (WRF) after discharge has not been investigated as extensively as baseline renal function at ad...

The mitotic checkpoint inhibits the anaphase promoting complex/cyclosome (APC/C) in the presence of unattached kinetochores and silences this inhibition once all kinetochores are stably attached to spindle microtubules. Checkpoint activity (i.e., APC/C inhibition) and silencing are correlated with changes in the kinetochore localization of checkpoint proteins, including Mad1, Mad2, Bub1, BubR1,...

Sir, Albert Einstein was arguably the greatest physicist in the 20th century and his extraordinary intelligence has long intrigued both scientists and the general public. Despite several studies that focused mainly on the histological and morphological features of Einstein’s brain after his death, the substrates of Einstein’s genius are still a mystery (Diamond et al., 1985; Anderson and Harvey...

Background-—Left atrial appendage (LAA) exclusion has been performed in patients with atrial fibrillation (AF) to prevent thrombus formation and subsequent cardioembolic events. Left atrial electrical remodeling is a recognized factor in the recurrence of AF. The effects of LAA exclusion on P-wave characteristics and left atrial electrical remodeling have not been well described. The purpose of...

Insect development has contributed significantly to our understanding of metazoan development. However, most information has been obtained by analyzing a single species, the fruit fly Drosophila melanogaster. Embryonic development of the red flour beetle Tribolium castaneum differs fundamentally from that of Drosophila in aspects suchasshort-germdevelopment, embryonic legdevelopment, extensive ...

It has been proposed that facial expression production originates in sensory regulation. Here we demonstrate that facial expressions of fear are configured to enhance sensory acquisition. A statistical model of expression appearance revealed that fear and disgust expressions have opposite shape and surface reflectance features. We hypothesized that this reflects a fundamental antagonism serving...

Mixtures of the ionic liquid (IL) [C6mim] [Tf2N] and acetonitrile have been investigated by a combination of dielectric relaxation spectroscopy (DRS) and ultrafast transient absorption techniques using the molecular probe 120-apo-b-carotenoic-120-acid (120CA). Steady-state absorption spectra of the 120CA molecule have also been recorded. The position of the probe’s S0 S2 absorption maximum corr...

The conformational changes underlying cysteine-loop receptor channel gating remain elusive and controversial. We previously developed a single-channel electrophysiological method that allows structural inferences about the transient open-channel conformation to be made from the effect and properties of introduced charges on systematically engineered ionizable amino acids. Here we have applied t...

D ow Dominant climatic factors controlling the lifetime peak intensity of typhoons are determined from six decades of Pacific typhoon data. We find that upper ocean temperatures in the low-latitude northwestern Pacific (LLNWP) and sea surface temperatures in the central equatorial Pacific control the seasonal average lifetime peak intensity by setting the rate and duration of typhoon intensific...

A calculation of dynamic polarizabilities of rovibrational states with vibrational quantum number v = 0–7 and rotational quantum number J = 0,1 in the 1ssg ground-state potential of HD + is presented. Polarizability contributions by transitions involving other 1ssg rovibrational states are explicitly calculated, whereas contributions by electronic transitions are treated quasi-statically and pa...