OBJECTIVE The in utero environment plays an important role in shaping development and later life health of the fetus. It has been shown that maternal genetic factors in the metabolic pathway of vitamin D associate with type 1 diabetes in the child. In this study we analyzed the genetic determinants of serum 25-hydroxyvitamin D (25OHD) concentration during pregnancy in mothers whose children lat...

PURPOSE/OBJECTIVES To determine the feasibility of collecting symptom data at home from school-age children with acute lymphoblastic leukemia (ALL) and from their fathers and mothers and to obtain initial descriptions of pain, sleep disturbance, and fatigue experienced by the family members at home. DESIGN Prospective and descriptive. SETTING Children's homes in Oregon and southwestern Wash...

OBJECTIVE To identify the social contextual factors, specifically the presence of information that supports v. undermines clinical recommendations, associated with infant feeding behaviours among mothers in low-income areas. DESIGN Cross-sectional survey evaluating social support networks and social relationships involved in providing care to the infant along with feeding beliefs and practice...

OBJECTIVE Since 1964, researchers have been examining the ways in which physicians deliver a postnatal diagnosis of Down syndrome (DS). Almost all of the studies, however, have been limited to reflections or very small sample sizes. The objective of this study was to document, in the most robust comprehensive way, the reflections of mothers in the United States who received diagnoses of DS for ...

objectives: the global prevalence of lifetime depression is very high among women in the world–approximately 12-25 percent. the global prevalence of disability is also very high and the estimated figure for the end of 2000 was put at around 300 million. the child’s disability stresses the mother the most, and this stress shows itself in the form of depression, and causes the mother’s performanc...

BACKGROUND After a child's death, parents may experience depression, posttraumatic stress disorder (PTSD), and increased risk for cancers, diabetes, psychiatric hospitalization, and suicide. Racial/ethnic differences are unknown. This longitudinal study investigated health and functioning of Hispanic, black, and white parents through 13 months after NICU/PICU death. METHODS Parents (176 mothe...

OBJECTIVE To describe the relation between maternal obesity, overweight and underweight status, and 16 categories of structural birth defects. DESIGN An ongoing multisite, case-control study. Clinical geneticists reviewed all of the cases, excluding those that had or were strongly suspected to have a single-gene disorder or chromosomal abnormality. Mothers with preexisting diabetes were also ...

OBJECTIVE The offspring of mothers who had diabetes during pregnancy experience increased risk later of diabetes and obesity later. We hypothesized that, in light of the historical improvements in the management of diabetes during pregnancy, these late consequences of the early environment might be diminishing with time. RESEARCH DESIGN AND METHODS Birth weight and information on BMI and gluc...

BACKGROUND AND OBJECTIVES Extremely preterm infants and infants born to adolescent mothers are at risk for adverse developmental. The objectives were to evaluate development and behavior outcomes of extremely low birth weight (ELBW) infants born to adolescent mothers <20 compared with adult mothers ≥20 years and to identify socioeconomic risk factors that affect outcomes. METHODS Retrospectiv...

OBJECTIVES 1) Examine the association between Black mothers' and daughters' body fatness, physical activity (PA) beliefs and levels of PA, and daughters' PA behavior; 2) determine whether family sociodemographic factors influence these relationships. DESIGN AND SETTING Cross-sectional; Black girls recruited from elementary schools in a low socioeconomic area. Data collected at the Georgia Pre...