نتایج جستجو برای: 60 hsp60

تعداد نتایج: 301710  

Journal: :Molecular medicine 1999
A Amberger M Hala M Saurwein-Teissl B Metzler B Grubeck-Loebenstein Q Xu G Wick

BACKGROUND Studies from our laboratory have shown that the earliest stages of atherosclerosis may be mediated by an autoimmune reaction against heat shock protein 60 (Hsp60). The interactions of Hsp60-specific T cells with arterial endothelial cells (EC) require expression of both Hsp60 and certain adhesion molecules shown to be induced simultaneously in EC by mechanical and other types of stre...

2013
Masako Tanabe Ryuichi Ishida Fumiko Izuhara Atsushi Komatsuda Hideki Wakui Kenichi Sawada Michiro Otaka Nobuhiro Nakamura Hideaki Itoh

The molecular chaperone HSP60 is a chaperonin homolog of GroEL. We had previously shown that the immunosuppressant mizoribine is bound directly to HSP60 and inhibited its chaperone activity. However, the inhibitory mechanisms of HSP60 by mizoribine have not yet been fully understood. In the present study, we investigated the influence of mizoribine on a folding cycle of HSP60 and co-chaperone H...

2005
Qingzhong Xiao Kaushik Mandal Georg Schett Johann Willeit Qingbo Xu

Background and Purpose—Previous work has shown that soluble heat shock protein 60 (HSP60; sHSP60), present in circulating blood, is associated with carotid atherosclerosis. In the current evaluation, we tested the hypothesis that sHSP60 levels are associated with the progression of carotid arteriosclerosis, prospectively. Methods—The association of sHSP60 with early atherogenesis (5-year develo...

2011
Jean-Eric Alard Sophie Hillion Loïc Guillevin Alain Saraux Jacques-Olivier Pers Pierre Youinou Christophe Jamin

BACKGROUND Heat shock protein (hsp) 60 that provides "danger signal" binds to the surface of resting endothelial cells (EC) but its receptor has not yet been characterized. In mitochondria, hsp60 specifically associates with adenosine triphosphate (ATP) synthase. We therefore examined the possible interaction between hsp60 and ATP synthase on EC surface. METHODOLOGY/PRINCIPAL FINDINGS Using F...

Journal: :American journal of physiology. Endocrinology and metabolism 2007
Hui-Chin Lai Tsun-Jui Liu Chih-Tai Ting Jia-Ying Yang Lan Huang Douglas Wallace Peter Kaiser Ping H Wang

Insulin deficiency downregulates HSP60 and IGF-I receptor signaling and disrupts intracellular signaling homeostasis in diabetic cardiac muscle. Our previous studies had shown that IGF-I receptor signaling can be modulated by the abundance of HSP60. Since HSP60 localizes to the cytoplasmic compartment and mitochondria, this study was carried out to determine the distribution of cytosolic and mi...

2017
Bojana Jakic Maja Buszko Giuseppe Cappellano Georg Wick

Atherosclerosis is the leading cause of death in the world. We have previously shown that expression of heat shock protein 60 (HSP60) on the surface of endothelial cells is the main cause of initiating the disease as it acts as a T cell auto-antigen and can be triggered by classical atherosclerosis risk factors, such as infection (e.g. Chlamydia pneumoniae), chemical stress (smoking, oxygen rad...

Journal: :The Journal of Experimental Medicine 1994
W Richter T Mertens B Schoel P Muir A Ritzkowsky W A Scherbaum B O Boehm

Molecular mimicry between viral antigens and host proteins was often suggested to be involved in induction of autoimmune diseases. In type 1 diabetes where pancreatic beta cells are destroyed by autoimmune phenomena, a linear sequence homology between a major autoantigen, glutamate decarboxylase (GAD), and the 2C protein of coxsackie B4 was identified. In addition, a sequence homology between G...

ژورنال: :مجله علوم پزشکی رازی 0
نور امیرمظفری n. amir mozaffari, microbiology department. faculty of medicine.دانشکده پزشکی، گروه میکروب شناسی، فریده قاضی f. ghazi, دانشکده پزشکی، گروه میکروب شناسی امرا... مصطفی زاده a. mostafazadeh, دانشکده پزشکی، گروه میکروب شناسی و ایمنی شناسی، علی مصطفائی a. mostafaii, دانشکده پزشکی، گروه میکروب شناسی و ایمنی شناسی، رمضان رجب نیا r. rajabnia,

زمینه و هدف: بروسلوز، یکی از مهمترین بیماریهای مشترک بین انسان و دام است که بر اثر آلودگی با باکتری های جنس بروسلا(بخصوص بروسلاملی تنسیس) به وجود می آید. وقتی بروسلا در معرض افزایش درجه حرارت قرار می گیرد، پروتئین های شوک حرارتی سنتز می کند. در این مطالعه، بروسلاملی تنسیس تحت شوک حرارتی در حرارتهای مختلف قرار می گیرد که تحت این شوک ها، (hsp)heat shock proteinها سنتز می شوند. سپس با استفاده از ر...

Journal: :American journal of physiology. Heart and circulatory physiology 2007
Sanjiv Gupta A A Knowlton

The heat shock proteins (HSP) are a highly conserved family of proteins with critical functions in protein folding, protein trafficking, and cell signaling. These proteins also protect the cell against injury. HSP60 has been found in the extracellular space and has been identified in the plasma of some individuals. HSP60 is thought to be a "danger signal" to the immune system and is also highly...

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