Activated T cells have been implicated in chronic rhinosinusitis (CRS) and asthma and physically interact with epithelial cells in the airways. We now report that human airway epithelial cells display significant constitutive cell-surface expression of costimulatory ligands, B7-H1, B7-H2, B7-H3, and B7-DC. Expression of B7-H1 and B7-DC was selectively induced by stimulation of either BEAS2B or ...

B7-DC is a recently discovered member of the B7 family that binds to PD-1 and is selectively expressed by dendritic cells (DCs). It has been shown to either costimulate or inhibit T cell responses. To assess the role of B7-DC in DC-T cell interactions, DCs from B7-DC knockout (KO) mice were generated and compared with DCs from wild-type (WT) and B7-1/B7-2 double KO mice. B7-1/B7-2-deficient DCs...

There are some plants can replaced grass among cover plants. Cover plants are obvious solution of problem in these places that the most important plant is Frankinia and Lisimakia etc. The aim of this study is to use organic wastes, biological fertilizers and moisture super absorbents in the growth media of Frankinia to increase water holding capacity, delay in permane...

abstract in order to investigate the effect of different ratios of cocopeat and vermicompost as a cultural media on seed emergence and some qualitative and quantitative characteristics of sweet pepper transplant (cv. colifornia wonder). the treatments include: vermicompost + cocopeat (3:1), vermicompost + cocopeat (1:3), vermicompost + cocopeat (1:1) (v/v) and normal soil of transplant. the tre...

the main objective of this study was to determine the influence of vermicompost and biostimulant on the growth and biomass in the coriander plant height, wet weight of plant ,dry weight of plant and biomass yield. the experiment was carried out as factorial experiment in the base of randomized complete blocks design with eight treatments and three replications at research field of agriculture c...

We have previously shown that B7-2 (CD86)-transfected P815 tumor cells elicit tumor-eradicating immunity that leads to the regression of the B7-2+ P815 tumor after transient growth in normal DBA/2 mice. Here, we show that both the B7-2 and B7-1 (CD80) molecules contribute to the eradication of B7-2+ P815 tumors as treatment of the mice with both anti-B7-2 and anti-B7-1 mAb was required to preve...

Cytotoxic T lymphocyte antigen 4 (CTLA4) appears to negatively regulate T cell activation. One mechanism by which CTLA4 might antagonize T cell function is through inhibition of CD28 signaling by competing for their shared ligands B7-1 and B7-2. In addition, CTLA4 ligation could initiate a signaling cascade that inhibits T cell activation. To address whether CTLA4 could inhibit immune responses...

Cytotoxic T lymphocyte antigen 4 (CTLA4) appears to negatively regulate T cell activation. One mechanism by which CTLA4 might antagonize T cell function is through inhibition of CD28 signaling by competing for their shared ligands B7-1 and B7-2. In addition, CTLA4 ligation could initiate a signaling cascade that inhibits T cell activation. To address whether CTLA4 could inhibit immune responses...

The purpose of the present study was to evaluate the ability of an attenuated Salmonella enterica serovar Typhimurium vaccine strain to up-regulate B7-1 and B7-2 on antigen-presenting cells and to examine the functional roles these costimulatory molecules play in mediating immune responses to Salmonella and to an expressed cloned antigen, the saliva-binding region (SBR) of antigen I/II. In vitr...

in order to study the effect of fertilizer management on summer savory production, a field experiment was conducted at the agricultural research station, college of agriculture, ferdowsi university of mashhad, iran during growing season of 2009. a randomized complete block design with three replications was used. treatments included: 1) nitroxin biofertilizer 2) phosphate solubilizing bacteria ...