Due to the increased number of revision total hip arthroplasties (THAs) to correct pain secondary to fretting from modular hip stems, this study was conducted in an effort to correlate objective findings of serum cobalt (Co) levels, serum chromium (Cr) levels, and/or reactive tissue seen on metal artifact reduction sequence (MARS) magnetic resonance imaging (MRI) with a patient's need for revis...

BACKGROUND Both minimally invasive surgery (MIS) and computer-assisted surgery (CAS) for total hip arthroplasty (THA) have gained popularity in recent years. We conducted a qualitative and systematic review to assess the effectiveness of MIS, CAS and computer-assisted MIS for THA. METHODS An extensive computerised literature search of PubMed, Medline, Embase and OVIDSP was conducted. Both ran...

OBJECTIVE To assess the efficacy of a single intra-articular injection of triamcinolone hexacetonide (THA) in knee osteoarthritis (OA) and examine factors which may relate to treatment efficacy. METHODS Eighty four patients with clinical and radiographic evidence of knee OA were recruited and randomly allocated to receive either THA (20 mg in 1 ml) or placebo (0.9% normal saline, 1 ml). Follo...

Infection rates in primary (first-time) major joint arthroplasty continue to be a significant issue. The effect of antibiotic and antiseptic prophylaxis on outcomes for this type of surgery has not been adequately reviewed. A systematic search of the main databases for randomized controlled trials (RCTs) evaluating antibiotics and antiseptics was conducted to evaluate the predetermined endpoint...

BACKGROUND Natural products represent an important source for agents of cancer prevention and cancer treatment. More than 60% of conventional anticancer drugs are derived from natural sources, particularly from plant-derived materials. In this study, 2α, 3α, 19β, 23β-tetrahydroxyurs-12-en-28-oic acid (THA), a novel triterpenoid from the leaves of Sinojackia sarcocarpa, was isolated, and its ant...

INTRODUCTION Most computer-assisted navigation systems used in total hip arthroplasty (THA) reference the anterior pelvic plane, which connects the anterior superior iliac spines and the pubic symphysis. The pelvic tilt is defined as the angle between this anterior pelvic plane (APP) and a vertical line in the standing position. Important interindividual variations of this angle have been repor...

The autonomous mammotropie tumors (3I tT) studied have retained responsiveness to estrogen. Optimal growth of such tumors occurs at doses one-tenth tha t necessary to induce tumorous proliferation of mammotropie cells (Sit) in p i tu i ta ry glands in situ or in grafts or normal t)i tuitary tissue beneath the kidney capsule. The similari ty in sensitivity between normal 3 I t in situ and M:t in...

Recent genetic studies on the immune response suggest tha t idiotypic markers of antibodies are inherited. Id io typic cross-reactions were detected among the antibodies to the Group C carbohydra te from related rabbi ts while these same idiotypic specificities were not seen in unrela ted rabbi ts (1). Genetic studies with inbred mice immunized with various bacterial and synthet ic antigens ind...

BACKGROUND Little is known about the impact of the reason for revision total hip arthroplasty (THA) on the outcomes following revision THA. In this study, our objective was to assess the association of operative diagnosis with patient-reported outcomes (PROs) after revision THA. METHODS We used prospectively collected data from the Mayo Clinic Total Joint Registry that collects pre- and post-...

CONTEXT Although prevalence of obesity and incidence of total joint arthroplasty (TJA) have dramatically increased over the last two decades in the U.S., little is known of the preoperative and postoperative weight patterns of patients undergoing TJA. OBJECTIVE To describe the preoperative and postoperative weight patterns of patients undergoing TJA and evaluate characteristics associated wit...