Carbodiimide reacts with isocyanide catalyzed by copper(i) iodide, leading to benzoimidazo[1,5-a]imidazoles in good yields. This reaction is efficient, and proceeds through a formal [3+2] cycloaddition and C-N coupling.

A convenient synthetic method for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetra substituted imidazole derivatives, has been developed via one-pot condensation reaction in solvent-free condition when aldehyde, ammonium acetate/amine, and 1,2-diketone are reacted using 0.8 mol% of NP-LaMnO3 at 80 °C under solvent free conditions. Catalyst could be recovered and reused in five reaction c...

Correction for ‘Electrochemically-mediated C–H functionalization of allenes and 1,3-dicarbonyl compounds to construct tetrasubstituted furans’ by Mu-Xue He et al. , Org. Chem. Front. 2022, DOI: 10.1039/d1qo01458g.

Starting from commercially available amines and propargylamides a variety of substituted imidazoles were synthesized via a novel hydroamination-cyclization sequence. The target compounds are obtained in good to excellent yields in the presence of catalytic amounts of zinc triflate.

A series of 5-sulphanyl derivatives of 1-Benzyl-2-alkyl-4-nitro-1H-imidazoles (5-9) were prepared by the coupling method of 3-(1-Benzyl-2-ethyl-4-nitro-1H-imidazole-5ylsulfanyl)propanoic acid (4) with appropriate amino acid ester hydrochloride, in the presence of hydroxybenzotriazole (HOBT) and DCC. Compounds (10-12) and (13) were similarly synthesized using appropriate amino alcohols, and 1-su...

A model of deep stromal Candida albicans infection was established by injecting 25 microliters of a suspension containing 5 X 10(9) colony forming units/ml of the yeast into corneas of pigmented rabbits. In this model, the infection lasts for more than 8 days. Using quantitative techniques, the authors compared the efficacy of six topical antifungal agents in the presence of an intact epitheliu...

a general synthetic route to the synthesis of imidazoles has been developed using nano sbcl5/sio2 under solvent-free conditions. the multi-component reactions of aldehydes, benzil and ammonium acetate were carried out to afford some trisubstituted imidazole derivatives. this method provides several advantages like simple work-up, environmentally benign, and shorter reaction times along with hig...