Objective: Cancer is one of the major causes of death worldwide irrespective of the sex. The aim of the study was to design, synthesize, and identification of novel anti-proliferative agents that can potently target cancer. Methods: We are reporting the synthesis of the new series of N-substituted 2-(2-butyl-4-chloro-1H-imidazole-5-yl)-1H-benzo[d]imidazole derivatives and evaluated for their an...

Functionally substituted 1,2-benzisoxazoles are very important and promising heterocycles with various pharmacological activities. Benzoxazoles containing reactive 3-chloromethyl 5-amino groups practically unexplored derivatives in this series. In communication, the simple method for synthesis of N-[3-(chloromethyl)-1,2-benzisoxazol-5-yl]acetamide which is an interesting precursor preparation a...

Pirfenidone (5-methyl-1-phenyl-2(1H)-pyridone, PFD) is a small-molecule compound acting on multiple targets involved in pathological fibrogenesis and is effective to increase the survival of patients with fibrosis, such as idiopathic pulmonary fibrosis. However, PFD is not active enough, requiring a high daily dose. In this study, to keep the multiple target profiles, N₁-substituted phenylhydro...

2,3-dihydro-1H-pyrazoles were highly selectively synthesized via the Pd(0)-catalyzed coupling-cyclization reaction of 4-non-substituted 2-substituted 2,3-allenyl hydrazines with aryl iodides in moderate to good yields.

N. KAUSHIK1*, N. KUMAR2, AND A. KUMAR3 School of Pharmaceutical Sciences, IFTM University, Moradabad–244102, 1School of Medical and Allied Sciences, Department of Pharmacy, Galgotias University, Greater Noida, Gautam Budh Nagar–201306, 2Oxford College of Pharmacy, UPSIDC, M-G Road, Ghaziabad–201001, 3Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, Meerut–2...

This study aimed to synthesize quinolinone derivatives and investigate their cytotoxic activity. The compound 1-azacoumarin-3-carboxylic acid (2-oxo-1H-quinoline-3-carboxylic acid) was obtained via the cyclocondensation of 2-hydroxybenzaldehyde with diethyl malonate in base catalyst give ethyl coumarin-3-carboxylate, followed by ammonolysis ester (ethyl coumarin-3-carboxylate) ammonia presence ...

synthesis of 2-[2-(2,6-dichlorophenyl)amino]phenylmethyl-3-[4-(2-substitutedphenyl-4-oxo-thiazolidinyl)aryl]-6-bromo quinazolin-4(3h)ones via-j have been achieved from the starting material 2-[(2,6-dichlorophenyl)amino] phenylacetic acid i to benzoxazine iii, further reaction with p-phenylindiamine and substituted aromatic aldehyde gave 2-[2-(2,6-dichlorophenyl)amino]phenyl methyl-3-(4-aminoary...