introduction: the role of brain tissues oxidative damage in learning and memory impairments has been well documented. it is also well known that thyroid hormones have a critical role for the brain functions. the purpose of this study was to investigate the role of brain tissues oxidative damage as a possible mechanism of deleterious effects of propylthiouracil (ptu) - induced hypothyroidism on ...

this study examined the effects of a protein rich diet on coping neurotransmitter levels in orally administered ampicillin–induced neurotoxic rats compared with propionic acid (pa) models of autism. 40 young male western albino rats were divided into four groups. the first group served as control and received phosphate buffered saline orally; the second group serving as autistic model was treat...

background and objective: although diabetes mellitus is known to be one of the risk factors for dementia but neuropathic changes in the brain of diabetic patients have not been completely revealed. therefore, this research study was done to evaluate structural changes in pyramidal neurons of hippocampal ca1 area of male diabetic rats using golgi-impregnation method. materials and methods: male ...

PURPOSE To investigate the effect of catechin on apoptotic cell death in the lens epithelium of rats with cataract. METHODS Cataract was induced by intraperitoneal injection of 100 mg/kg N-methyl-N-nitrosourea (MNU) to ten day-old Sprague-Dawley rats. The neonatal rats were randomly divided into five groups (n=15 in each group): a control group, and four cataract-induction groups, treated wit...

Background: Oleuropein is a phenolic compound which is present in the olive leaf extract. The purpose of the present study was to investigate the neuroprotective effect of oleuropein as an antioxidant agent on the substantia nigra in aged rats. Methods: Twenty 18-month-old Wistar rats (450-550 g) were randomly divided into control and experimental groups. The experimental group received a daily...

Objective: Aging is associated with some changes in the liver function including increased collagen deposition and decreased mitochondrial function. This study aims to evaluate effect of resistance exercise vitamin C intake on expression Peroxisome Proliferator-Activated Receptor-? Coactivator-1? (PGC-1?) Mitofusin 1 (MFn1) genes older rats. Methods: an experimental conducted 25 male Wistar rat...

Centella asiatica extract on cognition and hippocampal pathology of mild chronic cerebral hypoperfusion (CCH) that was induced by permanent right common carotid artery occlusion (RCO) in rats. Materials and Methods: Sixty-four male Sprague-Dawley rats were randomly divided into four groups of Sham-veh, Sham-C. asiatica, RCO-veh and RCO-C. asiatica, which were further divided into short-term and...

Background and Objectives Continuous exercise with moderate intensity the use of nanocurcumin supplementation has potential to control reduce tumors central nervous system, including glioblastoma. We assessed simultaneous effect moderate-intensity continuous exercises on STAT3 gene expression in mice glioblastoma multiforme brain tumors. Subjects Methods Thirty-five male Wistar rats were random...