نتایج جستجو برای: 4 hydroxy 2 nonenal

تعداد نتایج: 3126698  

2015
Jing Yang Keri A. Tallman Ned A. Porter Daniel C. Liebler

Protein alkylation by 4-hydroxy-2-nonenal (HNE), an endogenous lipid derived electrophile, contributes to stress signaling and cellular toxicity. Although previous work has identified protein targets for HNE alkylation, the sequence specificity of alkylation and dynamics in a cellular context remain largely unexplored. We developed a new quantitative chemoproteomic platform, which uses isotopic...

Journal: :The Biochemical journal 2009
Bradford G Hill Sunday O Awe Elena Vladykovskaya Yonis Ahmed Si-Qi Liu Aruni Bhatnagar Sanjay Srivastava

Myocardial ischaemia is associated with the generation of lipid peroxidation products such as HNE (4-hydroxy-trans-2-nonenal); however, the processes that predispose the ischaemic heart to toxicity by HNE and related species are not well understood. In the present study, we examined HNE metabolism in isolated aerobic and ischaemic rat hearts. In aerobic hearts, the reagent [(3)H]HNE was glutath...

2014
Antonio Ayala Mario F Muñoz Sandro Argüelles

Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs). Over the last four decades, an extensive body of literature regarding lipid peroxidation has shown its important role in cell biology and human health. Since the early 1970s, the total publish...

Journal: :Free radical biology & medicine 2016
Sumitra Miriyala Chadinee Thippakorn Luksana Chaiswing Yong Xu Teresa Noel Artak Tovmasyan Ines Batinic-Haberle Craig W Vander Kooi Wang Chi Ahmed Abdel Latif Manikandan Panchatcharam Virapong Prachayasittikul D Allan Butterfield Mary Vore Jeffrey Moscow Daret K St Clair

Cardiovascular complications are major side effects of many anticancer drugs. Accumulated evidence indicates that oxidative stress in mitochondria plays an important role in cardiac injury, but how mitochondrial redox mechanisms are involved in cardiac dysfunction remains unclear. Here, we demonstrate that 4-hydroxy-2-nonenal (HNE) activates the translocation of the mitochondrial apoptosis indu...

2014
Jolanta Czerwińska Jarosław Poznański Janusz Dębski Zuzanna Bukowy Vilhelm A. Bohr Barbara Tudek Elżbieta Speina

4-Hydroxy-2-nonenal (HNE) is a reactive α,β-unsaturated aldehyde generated during oxidative stress and subsequent peroxidation of polyunsaturated fatty acids. Here, Werner protein (WRN) was identified as a novel target for modification by HNE. Werner syndrome arises through mutations in the WRN gene that encodes the RecQ DNA helicase which is critical for maintaining genomic stability. This her...

Journal: :Journal of neuropathology and experimental neurology 2003
Kathrin R Sidell Kathleen S Montine Matrhew J Picklo Sandra J Olsen Ventkataraman Amarnath Thomas J Montine

4-Hydroxy-2-nonenal (HNE), a potent toxin formed in the brain from oxidation of polyunsaturated fatty acids, is increased in Alzheimer disease (AD), where it is a proposed effector of amyloid beta peptide-mediated neurotoxicity. Detoxification of HNE via the mercapturic acid pathway (MAP) is the primary means by which other organs, such as liver, limit its toxic effects. Here we examined the di...

2008
Takayuki Takimoto Mitsuhiro Yoshida Haruhiko Hirata Mayumi Suzuki Masahiko Yanagita Yozo Kashiwa Koji Inoue Yukihiro Yano Shigenori Hoshino Yoshito Takeda Sho Goya Takashi Kijima Toru Kumagai Tadashi Osaki Isao Tachibana Ichiro Kawase

4-Hydroxy-2-nonenal (4-HNE), a major product generated during oxidative stress, exhibits cytotoxic effects; however, the mechanisms of 4-HNE-induced endothelial cell injury are not well defined. To explore this issue, we examined how 4-HNE damages human umbilical vein endothelial cells (HUVECs) and found that 4-HNE induced biphasic activation of c-Jun N-terminal kinase (JNK). Both preand post-t...

Journal: :Current opinion in clinical nutrition and metabolic care 2012
Fang Cai Yves Marc Dupertuis Claude Pichard

PURPOSE OF REVIEW The review aims at elucidating the role of lipid peroxidation of polyunsaturated fatty acids (PUFAs) in colorectal cancer (CRC) risk and treatment. RECENT FINDINGS CRC is one of the most overriding threats to public health. Despite a broad range of treatments, up to 50% of patients will inevitably develop incurable metastatic disease. Peroxidation of PUFAs contributes to aug...

Journal: :Acta biochimica Polonica 2010
Morana Jaganjac Tanja Matijevic Marina Cindric Ana Cipak Lidija Mrakovcic Wolfgang Gubisch Neven Zarkovic

Oxidative stress, i.e., excessive production of oxygen free radicals and reactive oxygen species, leads to lipid peroxidation and to formation of reactive aldehydes which act as second messengers of free radicals. It has previously been shown that oxidative stress may be involved in the transcriptional regulation of cytomegalovirus (CMV) immediate early promoter, involved in viral reactivation ...

2010
Noriyuki Shibata Yuri Inose Sono Toi Atsuko Hiroi Tomoko Yamamoto Makio Kobayashi

Recent studies have suggested implications for α-synuclein cytotoxicity in the pathomechanism of multiple system atrophy (MSA). Given in vitro evidence that α-synuclein generates oxidative stress, it is proposed that lipid peroxidation may be accelerated in MSA. To address this issue, we performed an immunohistochemical analysis of protein-bound 4-hydroxy-2-nonenal (P-HNE) in sections of archiv...

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