Benzo(a)pyrene (BP) and several benzo-ring derivatives of BP were tested for carcinogenic activity in mice by topical application of each compound once every 2 weeks for 60 weeks. Chronic treatment of C57BL/6J mice with (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene (0.025 to 0.10 micronmole/application) indicated that the dihydrodiol was slightly more active as a complete carcinogen than ...

Xylaria, belonging to the Ascomycotina, is known to produce diverse classes of bioactive substances. In an effort to identify the chemical constituents of the fruiting bodies of Xylaria polymorpha, linoleic acid (1), linoleic acid methyl ester (2), ergosterol (3), 4-acetyl-3,4-dihydro-6,8-dihydroxy-3-methoxy-5-methyl-1H-2-benzopyran-1-one (4), and 4-hydroxyscytalone (5) were isolated from its m...

1,4-Dihydroxy-2-naphthoate [1, 21 as the crucial intermediate in the biosynthesis of menaquinones in bacteria is formed from shikimate [3] via chorismate [2] and o-succinylbenzoate [I]. Prenylation [4] and methylation [I] result in formation of menaquinones of different length of side chain. The principal steps of the synthesis of the naphthoquinone moiety are similar for both plants and bacter...

In modern world, there is a need to search for alternatives antibiotics due the growing resistance of microorganisms. Plant extracts can be promising replacement. Due biological functions, they suppress development various processes associated with pathogenicity and virulence, in particular, Quorum sensing process. Based on above, aim study was assess bioactivity 7,8-dihydroxy-4- methylcoumarin...

One new diterpene ester with a tricyclic lathyrane-or myrsinol-type skeleton has been isolated fromEuphorbia decipiensBoiss. &Buhse. In addition to one new, the known constituents -amyrin, -amyrin acetate, methyl (2,4-dihydroxy-3-formyl-6-methoxy) phenyl ketone (2), and 1,1-bis (2,6-dihydroxy-3-acetyl-4-methoxyphenyl)methane (3) have been isolated from the same source. The structure elucidation...

Dobriner, Rhoads, and Lavin (8, 9) isolated from the excreta of rats injected subcutaneously with 1,2,5,6_dibenzanthracene 1 a phenolic compound which was later shown by Cason and Fieser (3) to have an absorption spectrum identical with that of synthetic 4',8'-dihydroxy-i,2,5,6-dibenzanthracene (Fig. z); the same phenolic derivative was also present in the excreta of mice which had received sim...

In the title co-crystal solvate, 2-ethoxy-benzamide-2,5-dihydroxy-benzoic acid-ethanoic acid (2/1/1), 2C(9)H(11)NO(2)·C(7)H(6)O(4)·C(2)H(4)O(2), two nonsteroidal anti-inflammatory drugs, ethenzamide (systematic name: 2-ethoxy-benzamide) and gentisic acid (systematic name: 2,5-dihydroxy-benzoic acid), together with acetic acid (systematic name: ethanoic acid) form a four-component mol-ecular ass...

Two new phenylethanoid glycosides integrifoliosides A (2) and B (3), along with a known phenylethanoid glycoside alyssonoside (1) and a flavone glucoside chrysoeriol-7-O-beta-D-glucopyranoside (4) were isolated from the aerial parts of Phlomis integrifolia. The structures of the new compounds were identified as 3,4-dihydroxy-beta-phenylethoxy-O-beta-D-apiofuranosyl-(1 --> 4)-alpha-L-rhamnopyran...