A series of novel arylpiperazines bearing a pyrrolidin-2-one fragment were synthesized and evaluated for their binding affinity for alpha1- and alpha2-adrenoceptors (ARs) as well as their antiarrhythmic and antihypertensive activities. The highest affinity for the alpha1-AR was displayed by 1-{3-[4-(2-chloro-phenyl)-piperazin-1-yl]-propyl}-pyrrolidin-2-one 7, which binds with a pKi = 7.13. The ...

A series of novel 1[5"-(2"'-substituted phenyl)-4",5"'-dihydro isoxazole-3"-yl]-3-[(4 substituted phenyl)imino]1-3-dihydro-2H-indole-2-one were synthesized from different substituted chalconised indole-2,3-dione was prepared from the different chalconised Isatin. The structures of the compounds were elucidated by elemental and spectral (IR, (1)H NMR, and MS) analysis. The synthesized compounds ...

Previous studies indicate that the CB1 cannabinoid receptor antagonist, N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-met hyl-1H-pyrazole-3-carboxamide HCl (SR141716A), inhibits the anandamide- and delta9-tetrahydrocannabinol- (THC) induced hypotension and bradycardia in anesthetized rats with a potency similar to that observed for SR141716A antagonism of THC-induced neurobehav...

Using the photocurable electrolyte solution containing viologen derivative 1,1′-bis- (4-vinylbenzyl)-4,4′-bipyridinium dihexafluorophosphate (EV 2+ •2PF 6 − ) and its composite of EV triphenylamine N,N′ -di(4-((3-(triethoxysilyl)-propyl)imino)methyl)phenyl- -diphenyl-4,4′-biphenyldiamine (TPB-PSSO) as electrochromic active layer, respectively, flexible devices (FECDs) were prepared by technolog...

We previously reported that (Z)-2-(4-[(5-methyl-2-phenyl-1, 3-oxazol-4-yl)methoxy]benzyloxyimino)-2-(4-phenoxyphenyl)acetic acid (3) showed potent glucose and lipid lowering effects in genetically obese and diabetic mice, KKA(y). This compound also showed transcriptional activity for peroxisome proliferator-activated receptor (PPAR)-gamma. We expanded on the structure-activity relationships of ...

In the title complex, [Ni(C(18)H(14)NO)(2)], the Ni(II) ion lies on an inversion center and is coordinated in a slightly distorted square-planar environment. The 1-[(4-methyl-phen-yl)imino-meth-yl]-2-naphtho-late ligands are coordinated in a trans arrangement with respect to the N and O atoms. In the symmetry-unique ligand, the dihedral angle between the naphthalene ring system and the benzene ...