Purified cardiac sarcolemmal membrane vesicles were used to determine if specific prostaglandin (PG) receptors are present on the myocyte. Two binding sites for PGE2 were identified in isolated bovine sarcolemmal membranes: a high-affinity site with a dissociation constant (Kd) of 0.32 nM and a maximum binding (Bmax) of 376 fmol/mg of protein and a lower-affinity site with a Kd of 3.41 nM and a...

A methylphosphonate derivative of BrdUrd3 is an inhibitor of the cellular uptake of 5F[6-3H]dUnd and other nucleosides (19). BrdUnd-OPO2Me also produces a delayed inhibitory effect on the growth of culture cells (18). The preparation and chemical properties of BrdUrd-OPO2Me have been re ported (18); the methylphosphonate ester linkage is not attacked by the phosphomonoesterases (8). Membrane tr...

In this study, series of ring-substituted 2-styrylquinazolin-4(3H)-one and 4-chloro-2-styrylquinazoline derivatives were prepared. The syntheses of the discussed compounds are presented. The compounds were analyzed by RP-HPLC to determine lipophilicity. They were tested for their inhibitory activity on photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Prima...

Chitosan-grafted-poly(4-vinylpyridine) (Cs-PVP) copolymers could be synthesized under heterogeneous conditions in presence of a potassium persulfate and sodium sulfite redox system. The synthesized graft copolymer could be utilized effectively, in the form of beads, as an efficient catalyst for Michael additions of active methylenes to functionally substituted alkenes. Moreover, methyl moiety o...

vilsmeier-haack reaction of 2,3,3-trimethyl-3h-benzo[g]indole, then aqueous basic work-up, leads to benzo[g]indol-2-ylidene- malondialdehydes. these react with various arylhydrazines and quinolin-2-ylhydrazine to form 3,3-dimethyl-2-(1-aryl-1h-pyrazol-4-yl)- 3h-benzo[g]indoles in good yields.

The isolation of steroid compounds from Adam Hawa leaves has been carried out through maceration, partition, separation, and purification. relatively pure BF2 isolate was 7 mg amorphous with a melting point 158-1700C. Results 1H-NMR spectrum analysis CDCl3 solvent, 500 MHz δH: 7,53 (d, J= 5,4 Hz, = C-H ); 7,72 5,7 C-H); 5,35 (1H, d, J=5,15 =C-H); 3,51 m, Ar-CH), 0,93 6,2 3H), 0,86 (3H, s), 0,84...