Quinazolinedione is one of the most notable pharmacophores in drug discovery due to its broad spectrum biological activities including antimalarial, anticancer, anti-inflammatory, and others. TCMDC-125133, whose structure features a quinazolinedione core, exhibits promising antimalarial activity low toxicity as described GlaxoSmithKline (GSK) report. Herein, concise four-step synthesis towards ...

BACKGROUND Plasmodium falciparum the main causative agent of malaria is an important public health vector. With the use of PCR, its genetic diversity has been extensively studied with dearth information from Nigeria. METHODS In this study, 100 P. falciparum strains merozoite surface protein 1(msp-1), merozoite surface protein 2 (msp-2) and Glutamate rich protein (Glurp) from Ogun State Genera...

OBJECTIVE RTS,S, a candidate vaccine for malaria, is a recombinant protein expressed in yeast containing part of the circumsporozoite protein (CSP) sequence of 3D7 strain of Plasmodium falciparum linked to the hepatitis B surface antigen in a hybrid protein. The RTS,S antigen is formulated with GSK Biologicals' proprietary Adjuvant Systems AS02(A) or AS01(B). A recent trial of the RTS,S/AS02(A)...

BACKGROUND Plasmodium falciparum infection can progress unpredictably to severe forms including respiratory distress and cerebral malaria. The mechanisms underlying the variable natural course of malaria remain elusive. METHODS The cerebral microvascular endothelial cells-D3 and lung endothelial cells both from human were cultured separately and challenged with P. falciparum field isolates ta...

Gene expression patterns have been demonstrated to be highly variable between similar cell types, for example lab strains and wild strains of Saccharomyces cerevisiae cultured under identical growth conditions exhibit a wide range of expression differences. We have used a genome-wide approach to characterize transcriptional differences between strains of Plasmodium falciparum by characterizing ...

BACKGROUND In the agenda towards malaria eradication, assessment of both malaria exposure and efficacy of anti-vectorial and therapeutic strategies is a key component of management and the follow-up of field interventions. The simultaneous use of several antigens (Ags) as serological markers has the potential for accurate evaluation of malaria exposure. Here we aimed to measure the longitudinal...

Malaria is a neglected tropical disease that still demands serious efforts to tackle successfully, including the need for new antimalarial lead compounds combat drug-resistant Plasmodium. Intensive phytochemical and pharmacological investigation into Indonesian medicinal plants Swietenia mahagoni Pluchea indica successfully revealed 5 constituents. Antimalarial bioassays indicated 34,5-tri- O-c...

conclusions pci was accompanied by some improvement in left atrial deformation indices as assessed by tissue doppler imaging. revascularization can, therefore, improve patient outcome. results regarding changes in left trial functional parameters after pci, those such as the strain of the septal wall and the anterior and inferior walls and the strain rate of the anterior and lateral walls signi...

Malaria is one of the most prevalent, devastating parasitic infectious diseases in the world. In an attempt to search for new antimalarial compounds efforts are being made to do preliminary screening of aerial parts of the plant Citrus aurantifolia (Christm.) Swingle (family Rutaceae) at early flowering and fruiting stages against chloroquine sensitive Plasmodium falciparum 3D7 strain. The plan...