We studied the frequency-dependent effects of quinidine on the right ventricular action potential and QRS duration in 10 patients (nine men and one woman; mean age, 57 +/- 14 years) undergoing electrophysiologic studies for clinical indications. The right ventricular monophasic action potential, electrocardiographic, and conventional intracardiac electrical signals from various sites were recor...

Agrin is an extracellular matrix (ECM) protein with a calculated relative molecular mass of more than 200 kD that induces the aggregation of acetylcholine receptors (AChRs) at the neuromuscular junction. This activity has been mapped to its COOH terminus. In an attempt to identify the functions of the NH2-terminal end, we have now characterized full-length chick agrin. We show that chick agrin ...

The toxicity of preservatives on conjunctival epithelium has been widely described in glaucomatous patients topically treated, suggesting both an indirect effect on the lacrimal film and a direct toxic action on epithelial cells (1). Previous studies indicate that long-term administration of preservative-containing eyedrops can lead to chronic conjunctival inflammation, ocular surface impairmen...

AlSi11 matrix composites reinforced with SiC particles have been fabricated by high pressure die casting assisted ultrasonic mixing. Severe plastic deformation process was performed on the as cast AlSi/2wt.%SiC composite using modified channel twisted output (TCAP) at three temperatures of 350, 400 and 450 °C. The TCAP tool consists helical part in horizontal area allowing for simulation back t...

1 Division of Brain Sciences, Department of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK 2 Reta Lila Weston Institute of Neurological Studies, Department of Molecular Neuroscience, University College London, London WC1N 1PJ, UK 3 Wellcome Department of Imaging Neuroscience, UCL Institute of Neurology, University College London WC1N 3BG, UK 4 Section of Neurology, ...

áeñ = 2.22 in the infiltrated one (reducing the contrast at the same time). After inversion the mean dielectric constant decreases to áeñ = 1.41 and, accordingly, the L pseudogap energy shifts upwards (see Fig. 5). The peak width is a function of both the dielectric contrast and the filling factor of the structure. Bare opals present a contrast eSiO2/eair = 2.1 that shifts to epolymer/eSiO2 = 1...

This paper describes MITRE’s participation in the native language identification (NLI) task at BEA-8. Our best effort performed at an accuracy of 82.6% in the eleven-way NLI task, placing it in a statistical tie with the best performing systems. We describe the variety of machine learning approaches that we explored, including Winnow, language modeling, logistic regression and maximum-entropy m...