The chemokine receptor CXCR4 is expressed in many cancers where it may regulate tumor cell growth and migration. The role of CXCR4 in cancer will depend on it being in an activated, signaling state. To better define the significance of CXCR4 expression in cancer, we developed an antibody that can distinguish CXCR4 phosphorylated on serine 339, a residue previously identified as a site for ligan...

The distance to the black hole binary GX 339–4 remains a topic of debate. We examine high-resolution optical spectra of the Na D lines resolving the velocity structure along the line of sight. We find this to be complex, with at least nine components, mostly blue-shifted, spanning a velocity range of nearly 200 km s −1. The presence of components with a large blue-shift rules out a nearby locat...

tural elucidation of eighteen new and sixteen known acyl glucoses having caffeoyl, coumaroyl and hexahydroxydiphenoyl groups from Balanophora japonica M. (Balanophoraceae) collected in Nagasaki Perfecture, Japan which was used as an antipyretic, an antitode and a hemostatic medicine in China. In a continuation of our studies on the chemical constituents of medicinal parasitic plants, we further...

BACKGROUND The purposes of this study were to investigate the clinical outcomes of enterococcal bacteriuria and to determine whether current management is adherent to Infectious Diseases Society of America guidelines. METHODS We conducted a retrospective medical record review of patients from 2 academic teaching hospitals for 3 months (September 1 through November 30, 2009). Patients were cla...

We report on a comprehensive and consistent investigation into the X-ray emission from GX 339-4. All public observations in the 11 year RXTE archive were analysed. Three different types of model single powerlaw, broken powerlaw and a disc + powerlaw were fitted to investigate the evolution of the disc, along with a fixed gaussian component at 6.4 keV to investigate any iron line in the spectrum...

Less toxic treatment options for patients with myeloperoxidase (MPO)-ANCA-associated GN are needed. Using an established murine model of focal necrotizing GN mediated by autoimmunity to MPO (autoimmune anti-MPO GN), we assessed the capacity for nasal tolerance induced by nasal insufflation of the immunodominant nephritogenic MPO peptide (MPO409-428) to attenuate this disease. Compared with mice...