In this editorial to the IJHCS Special Issue on Animal-­‐Computer Interaction (ACI), we provide an overview of the state-­‐of-­‐the-­‐art in this emerging field, outlining the main scientific interests of its developing community, in a broader cultural context of evolving human-­‐animal ...

Autologous chondrocyte implantation (ACI) is used widely as a treatment for symptomatic chondral and osteochondral defects of the knee. Variations of the original periosteum-cover technique include the use of porcine-derived type I/type III collagen as a cover (ACI-C) and matrix-induced autologous chondrocyte implantation (MACI) using a collagen bilayer seeded with chondrocytes. We have perform...

About 10 years ago the International Medical Informatics Association (IMIA) recognized the need for an applied informatics journal for the health sciences. In response to this need, the journal Applied Clinical Informatics (ACI) was launched in 2009 as a companion journal to Methods of Information in Medicine (MIM), both published by Schattauer (since January 1, 2017 part of Thieme), with the i...

Background Deciphering the amount of work provided by different co-authors of a scientific paper has been a recurrent problem in science. Despite the myriad of metrics available, the scientific community still largely relies on the position in the list of authors to evaluate contributions, a metric that attributes subjective and unfounded credit to co-authors. We propose an easy to apply, unive...

Ryanodine receptors (RyRs) are intracellular membrane channels playing key roles in many Ca signaling pathways and, as such, are emerging novel therapeutic and insecticidal targets. RyRs are so named because they bind the plant alkaloid ryanodine with high affinity and although it is established that ryanodine produces profound changes in all aspects of function, our understanding of the mechan...

The bile salt export pump (BSEP, ABCB11) is predominantly responsible for the efflux of bile salts, and disruption of BSEP function is often associated with altered hepatic homeostasis of bile acids and cholestatic liver injury. Accumulating evidence suggests that many drugs can cause cholestasis through interaction with hepatic transporters. To date, a relatively strong association between dru...

BACKGROUND Autologous chondrocyte implantation (ACI) can be used in the treatment of focal cartilage injuries to prevent the onset of osteoarthritis (OA). However, we are yet to understand fully why some individuals do not respond well to this intervention. Identification of a reliable and accurate biomarker panel that can predict which patients are likely to respond well to ACI is needed in or...

This paper uses computational simulation to investigate the lateral load-displacement behavior and failure modes of a modern 14-story reinforced concrete (RC) core wall building. The design complies with minimum code requirements current California Building Code, which is based on ASCE 7–16 ACI 318–14. representation building, accounts for material nonlinearities all structural components, empl...