Thirty-nine new thiazolide/thiadiazolide compounds were compared with the nitrothiazole nitazoxanide for activity against Cryptosporidium parvum development in HCT-8 cells. Twenty-seven agents exerted > or =90% inhibition. Agents with a lower 50% inhibitory concentration (IC(50)) than nitazoxanide were either NO(2) or halogen 5 substituted on the thiazole moiety. Other 5 substitutions such as m...

The title compound, C24H18N4S3, exhibits three near planar benzo-thia-zole systems in a pseudo-C 3 conformation. The dihedral angles between the planes of the benzo-thia-zole groups range from 112.56 (4) to 124.68 (4)° In the crystal, mol-ecules are connected to each other through three short C-H⋯N contacts, forming an infinite chain along [100]. The molecules are also linked by π-π interaction...

Administration of ambilhar or its N-acetyl derivative to rabbits resulted in a significant increase in urinary iron excretion, due to chelation. Substitution of the sulphur of thiazole by nitrogen abolished its metal chelating power. In vitro three different iron chelates were obtained, containing one or two iron atoms per mole of drug. However, in vivo studies revealed the presence of an ambil...

A series of thiazolo[5,4-d]thiazole-based small molecule organic optoelectronic materials is synthesized via a straightforward microwave-activated Pd-catalyzed C-H arylation protocol. The procedure allows us to obtain extended 2,5-dithienylthiazolo[5,4-d]thiazole chromophores with tailor-made energy levels and absorption patterns, depending on the introduced (het)aryl moieties and the molecular...

In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also...

New N,N-disubstituted β-amino acids and their derivatives with thiazole, aromatic, and heterocyclic substituents were synthesized from N-phenyl-N-thiocarbamoyl-β-alanine by the Hantzsch method; derivatives with hydrazone fragments were also obtained. Some of the synthesized compounds exhibited discrete antimicrobial activity, and 3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)(phenyl)amino]propanoic ac...

Although the structure of thiamin (vitamin B,) has been known for over 40 years (Williams, 1936; Grewe, 1936) and its chemical synthesis accomplished soon thereafter (Williams & Cline, 1936; Andersag & Westphal, 1937; Todd & Bergel, 1937), the biosynthetic pathway to thiamin (3) has still not been elucidated completely. It is well established that the pyrimidine (1) and thiazole (2) moieties ar...

3-[(2'-Substituted benzylidene amino thiazol-4'-yl) amino] coumarins (5a-5d) and 3-[(2'-Substitutd benzylidine amino oxazole-4'-yl) amino coumarins (8a-8d) were prepared by the reaction with compounds 4 and 7 respectively with various substituted aldehydes in the presence of glacial acetic acid. All the synthesized compounds 120 have been screened for their antibacterial and antifungal activiti...

We have designed and synthesized novel bis-thiazole derivative. A 4-[bis(thiazol-2-ylamino)methyl]phenol was efficiently prepared in 71% yield by the reaction of 2-aminothiazole with 4-hydroxybenzaldehyde ethanol for 24 h. The structure newly obtained compound characterized 1H, 13C NMR mass spectrometry. Bis-thiazole derivative exhibits high tyrosinase inhibitory activity an IC50 value 29.71 μM...