This paper presents an effective design methodology and flow, which is validated through three mmwave/sub-mm-wave amplifiers: including W-band LNA with NF=7dB, W-band PA with PAE >11% and D-band amplifier with gain>20dB. The CMOS based amplifiers can be integrated with III-V materials to form heterogeneous integration, such as COSMOS, to achieve the best performance for various applications.

Targeting protein kinases is a common approach for cancer treatment. In this study, series of novel terephthalic and isophthalic derivatives were constructed as potential type 2 kinase inhibitors adapting pharmacophore features approved anticancer drugs class. Inhibitory activity designed structures was studied in silico against various cancer-related compared with that known inhibitors. Obtain...

Substrate- and ligand-induced conformational changes were studied in a series of thiol-modified derivatives of rabbit muscle creatine kinase that retained different amounts of enzymic activity. The results indicate that the 'reactive' thiol group of the enzyme is required for the conformational changes associated with formation of a 'transition-state analogue' complex.

The crystal structure of rabbit muscle creatine kinase, solved at 2.35 A resolution by X-ray diffraction methods, clearly identified the active site with bound sulfates surrounded by a constellation of arginine residues. The putative binding site of creatine, which is occupied by a sulfate group in this analysis, has been tentatively identified. The dimeric interface of the enzyme is held toget...

Recent advances in advanced quantum chemistry and quantum chemistry interfaced with model potentials are discussed, with the primary focus on new scalable implementations in the GAMESS electronic structure suite of programs. Applications to solvent effects and surface science are discussed.

In the Postgenom era one of the remaining major challenges is the detailed understanding of protein networks within the living cell. Currently, there is a large gap between the detailed understanding of proteins in vitro and their description in interaction pathway maps in systems biology. In order to contribute to a more detailed understanding of protein interactions a combined approach of x-r...