Canine status epilepticus (CSE) is characterized by epileptic seizures that are longer than 5 min or more one seizure with incomplete recovery. Currently, diazepam suppositories generally prescribed for CSE. Levetiracetam (LEV) of the newest antiepileptic drugs currently available. This study compared pharmacokinetics intragastric and intrarectal administration in oral formula LEV four healthy ...

A steam distillation extraction kinetics experiment was conducted to estimate essential oil yield, composition, antimalarial, and antioxidant capacity of cumin (Cuminum cyminum L.) seed (fruits). Furthermore, regression models were developed to predict essential oil yield and composition for a given duration of the steam distillation time (DT). Ten DT durations were tested in this study: 5, 7.5...

There are increasing demands for syngas production. Fossil-based fuels expensive and environmentally unfriendly. Affordable, sustainable, healthy alternatives sustainable fuel sources needed. This study focused on producing tor-chars from two different tropical biomasses (from Nigeria, West Africa), which were torrefied characterized to improve their properties potential use as feedstocks in an...

Mouse brain contains at least 2 distinct spectrin subtypes: brain spectrin(240/235) and brain spectrin(240/235E) (Riederer et al., 1986). In this study, we demonstrate that these subtypes are differentially expressed during mouse brain development. Brain spectrin(240/235) can be detected in fetal tissue and increases 2-fold during brain development. This subtype is enriched in the cortical cyto...

Phasic coronary and aortic blood flow and arterial pressure were measured as heart rates were increased by ventricular pacing from 120 to 270 beats/min in unanesthetized dogs before and after beta-receptor blockade with intravenous propranolol. Before beta-receptor blockade, coronary flow progressively increased and coronary vascular resistance decreased with increasing heart rates. Aortic bloo...

A simple, rapid, accurate and precise analytical method for determination of secondary and tertiary amines in hydrochloride salt form of drug substances in non-aqueous medium, which does not require any derivatization, was developed by headspace gas chromatography. Dimethylamine hydrochloride and triethylamine hydrochloride were analyzed in metformin hydrochloride. The sample was dissolved in a...

Objective: The aim of presented study was to develop a high-performance liquid chromatography (HPLC) method with UV detection for simultaneous determination of ketoprofen, methyl paraben and propyl paraben in a gel formulation. Methods: The chromatography was carried out on a C18 Results: Under these chromatographic conditions, the obtained retention times were approximately 2.41 min for methyl...

Olives contain 3,4-dihydroxyphenyl compounds (catechols)-especially 3,4-dihydroxyphenylethanol (DOPET)-that have therapeutic potential as nutraceuticals. Whether olive ingestion affects plasma levels of free (unconjugated) catechols has been unknown. Arm venous blood was sampled before and 15, 30, 45, 60, 120, 180, and 240 min after six healthy volunteers ate 10 Kalamata olives. Catechols were ...

We examined the preliminary feasibility, tolerability and efficacy of single-dose, intravenous (i.v.) ketamine in depressed emergency department (ED) patients with suicide ideation (SI). Fourteen depressed ED patients with SI received a single i.v. bolus of ketamine (0.2 mg/kg) over 1-2 min. Patients were monitored for 4 h, then re-contacted daily for 10 d. Treatment response and time to remiss...