0377-2217/$ see front matter 2011 Elsevier B.V. A doi:10.1016/j.ejor.2011.01.014 ⇑ Tel.: +90 312 290 27 68; fax: +90 312 266 40 54. E-mail address: [email protected] In this paper, we study allocation strategies and their effects on total routing costs in hub networks. Given a set of nodes with pairwise traffic demands, the p-hub median problem is the problem of choosing p nodes as hub loca...

Long-chain acyl-CoA dehydrogenase (LCAD) catalyzes the first reaction of the mitochondrial beta-oxidation of fatty acids. We isolated and sequenced three cDNA clones encoding human LCAD precursor (p). The cDNAs encompass a 2217-base region including 5, 1290, and 922 bases in the 5'-noncoding, coding, and 3'-noncoding regions, respectively, and encodes the entire pLCAD of 430 amino acids (Mr: 47...

Results Out of 61 patients, 66% were male, aged from 1 to 11 at the time of their first allergic reaction (median: 3 years). Peanut allergy was documented in 52 patients. Sensitization was observed in 9 cases. 95% of patients had atopy: atopic dermatitis (62.3%), asthma (55.7%), allergic rhinitis (47.5%). Associated food sensitizations or allergies were: tree nuts (47.7%), legumes (36.4%), egg ...

Inhibition of mTOR signaling enhances antitumor memory lymphocytes. However, pharmacologic mTOR inhibition also enhances regulatory T-cell (Treg) activity. To counter this effect, Treg control was added tomTOR inhibition in preclinical models. Tregs were controlled with CD4-depleting antibodies because CD4 depletion has high translational potential and already has a well-established safety prof...

Background This cross-sectional study was conducted to compare the average costs of breast cancer screening and treatment among women with the age of 25 and over in Shiraz-Iran.   Methods Three majors hospitals affiliated with Shiraz University of Medical Sciences (SUMS) were selected for data collection. Financial documents and interviews with the hospitals’ financial officers were used for da...

The micro-RWELL detector (μ-RWELL) is a single amplification stage resistive Micro Pattern Gaseous Detector (MPGD), based on copper-clad polyimide foil patterned with micro-well matrix coupled the readout PCB through DLC film (10÷100MΩ/□). For phase-2 upgrade of LHCb experiment, proposed for LHC Run-5, excellent performance current muon will need to be maintained at 40 times pile-up level exper...