Background: Macrophage capping protein (CAPG), an actin filament end-capping protein, plays an important role in regulation of cellular motility and structural rearrangement within cells and has been implicated with development of various types of cancer. Recent study demonstrated that a CAPG variant was associated with a rare fallopian tube tumor, albeit with a small sample size. The present s...

STUDY OBJECTIVE The UK government called for a 40% reduction in cardiovascular disease mortality in those aged under 75 by 2010. This paper examines the potential for cardiovascular risk factor changes to reduce coronary heart disease deaths in Scotland, and then extrapolates the findings to the UK population. DESIGN Secondary analysis of published data using a previously validated mortality ...

Currently, accepted treatments for Female Sexual Dysfunction (FSD) are limited to psychological, behavioral, hormonal and psychopharmacologic interventions. Because of the complex and multifactorial nature of FSD, current therapeutic options may leave a subset of women suffering with sexual dysfunction without clinical improvement. As a simple, safe, and natural alternative therapeutic option f...

This article is part of a Minifocus on the ESCRT machinery. For further reading, please see related articles: ‘No strings attached: the ESCRT machinery in viral budding and cytokinesis’ by Bethan McDonald and Juan Martin-Serrano (J. Cell Sci. 122, 2167-2177) and ‘How do ESCRT proteins control autophagy?’ by Tor Erik Rusten and Harald Stenmark (J. Cell Sci. 122, 2179-2183). The endosomal sorting...

Aim: This study was conducted to assess depression and quality of life in the elderly and the factors influencing these methods. Methods: The sample of this descriptive study consisted of 450 individuals, 65 years of age and older, who presented to the Family Healthcare Centers in the provincial center of Erzincan between October 2010 and March 2011. The data were collected using a descriptive ...

Background: Short term studies of exercise training have shown benefits in cystic fibrosis. Transferring exercise programmes to the community and sustaining them long term is a challenge for the patient. The effectiveness of an individualised unsupervised home based exercise programme was examined in adults with cystic fibrosis over a 1 year period. Methods: Subjects were randomised to undertak...

In recent years, adaptive designs have recaptured attentions in the clinical research society as they can improve the flexibility and efficiency of conducting a clinical trial and increase the chance of trial success. However, adaptive trials are complex to design and often accompanied with various degrees of statistical, procedural, logistic and regulatory challenges. This article provides a g...

OBJECTIVE To investigate whether dietary nutrients can reduce the genetic risk of early age-related macular degeneration (AMD) conferred by the genetic variants CFH Y402H and LOC387715 A69S in a nested case-control study. METHODS For 2167 individuals (≥55 years) from the population-based Rotterdam Study at risk of AMD, dietary intake was assessed at baseline using a semiquantitative food freq...

Objective: To evaluate the dose-response effect of aerobic exercise on sleep duration, sleep efficiency and sleep quality in previously sedentary, moderately overweight men. Methods: In a randomized, controlled trial, 53 sedentary Caucasian men aged between 20 and 40 years (VO2max<45 mL O2 kg -1 min-1, BMI: 25-30 kg/m2, body fat>25%) completed a 13-week aerobic exercise intervention consisting ...