This article introduces the concept of S-2-absorbing primary submodule as a generalization 2-absorbing submodule. Let S be multiplicatively closed subset ring R and M an R-module. A proper N is said to if (N :R M) ? = there exists fixed element s such that whenever abm for some a,b m M, then either sam or sbm sab ?(N M). We give several examples, properties characterizations related concept. Mo...