Studies in 14 patients with unconjugated hyperbilirubinaemia caused by Gilbert's syndrome have revealed abnormalities of the enzymes of haem biosynthesis measured in peripheral blood cells. The activity of the penultimate enzyme of haem biosynthesis protoporphyrinogen (PROTO) oxidase was reduced at 3.1 +/- 2.6 nmol PROTO/g protein/h (mean +/- ISD) compared with 8.2 +/- 5.1 in controls (p less t...

The Proto spatial computing language [1] simplifies the creation of scalable, robust, distributed programs by abstracting a network of locally communicating devices as a continuous geometric manifold. However, Proto’s successful application in a number of domains is challenging its coherence across different platforms and distributions. We thus present a complete operational semantics for the P...

Most lymphoid malignancies are initiated by specific chromosomal translocations between immunoglobulin (Ig)/T cell receptor (TCR) gene segments and cellular proto-oncogenes. In many cases, illegitimate V(D)J recombination has been proposed to be involved in the translocation process, but this has never been functionally established. Using extra-chromosomal recombination assays, we determined th...

Preface Rough sets over generalized transitive relations like proto-transitive ones have been initiated by the present author in the year 2012 [1]. Subsequently [2], approximation of proto-transitive relations by other relations was investigated and the relation with rough approximations was developed towards constructing semantics that can handle fragments of structure. It was also proved that...

We report the detection of the J=2-1 line of DCO in the proto-planetary disk of DM Tau and re-analyze the spectrum covering the 465 GHz transition of HDO in this source, recently published by Ceccarelli et al. (2005). A modelling of the DCO line profile with the source parameters derived from high resolution HCO observations yields a DCO/HCO abundance ratio of ≃ 4×10−3, an order of magnitude sm...

Most lymphoid malignancies are initiated by specific chromosomal translocations between immunoglobulin (Ig)/T cell receptor (TCR) gene segments and cellular proto-oncogenes. In many cases, illegitimate V(D)J recombination has been proposed to be involved in the translocation process, but this has never been functionally established. Using extra-chromosomal recombination assays, we determined th...

In comparing deliberation to the analysis of a geometrical figure, Aristotle made a highly significant theoretical statement on design, which has largely gone unnoticed. Through an interpretation of the accounts given by Aristotle and the Greek geometer Pappus, seven features of the method of analysis can be identified, concerning the types of analysis, its stages, its start and end points, the...