By reaction of 6-mercaptopurine (Ia), with acetoxyhydrargyriobenzol resp. mercuric acetate the 6-(phenylhydrargyriothio)-purine (IIa) resp. bis-(6-purinylthio)hydrargyrium (IIIa) was obtained. Analogically were prepared from starting compound Ib-Id the 2-amino-6-(phenylhydrargyriothio)-purine (IIb), its 9-(1-ß-Dribofuranosyl)-derivative (IIc), 4-(phenyl-hydrargyriothio)-pyrazolo[3,4-d]pyrimidin...

The benzylindazole derivative 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) is an allosteric stimulator of soluble guanylate cyclase (sGC) that sensitizes the enzyme to the gaseous ligands carbon monoxide (CO) and nitric oxide (NO). In this study, we examined whether YC-1 also promotes the production of these gaseous monoxides by stimulating the expression of the inducible isoforms of ...

Abstract Pyrazolo[3,4-b]pyridine is a privileged scaffold found in many small drug molecules that possess wide range of pharmacological properties. Efforts to further develop and exploit synthetic methodologies permit the functionalization this heterocyclic moiety warrant investigation. To end, series novel 1,3-disubstituted pyrazolo[3,4-b]pyridine-3-carboxamide derivatives have been prepared b...

Combining two different metals for the synthesis of a metal–organic framework (MOF) is smart strategy architecture new porous materials. Herein, bimetal–organic (bimetal–MOFs) based on Fe and Co was synthesized. Then, phosphorous acid tags were decorated bimetal–MOFs via postmodification method as acidic functionalized catalyst. This catalyst used pyrazolo[4,3-e]pyridine derivatives suitable dr...

We report here the in vitro characterization of 1-(2-chlorophenyl)-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one (BAY 73-6691), the first potent and selective inhibitor of phosphodiesterase 9 (PDE9), which is currently under preclinical development for the treatment of Alzheimer's disease. This compound selectively inhibits human (IC50 = 55 nM) and murin...