ABSTRACT. Licorice-associated hypertension is thought to be due to increased renal sodium retention. The active compound of licorice, glycyrrhetinic acid (GA), inhibits renal 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) and by that mechanism increases access of cortisol to the mineralocorticoid receptor that causes renal sodium retention and potassium loss. In addition, a direct vas...

Hyperkalemia is a common life-threatening problem in hemodialysis patients. Because glycyrrhetinic acid (GA) inhibits the enzyme 11beta-hydroxy-steroid dehydrogenase II and thereby increases cortisol availability to the colonic mineralocorticoid receptor, it has the potential to lower serum potassium concentrations. To test this, 10 patients in a 6 month prospective, double-blind, placebo-contr...

Secondary metabolites are chemical found in plants. These have no role in plant growth but these are important for human because it have many pharmacological activity. Bergenia species such as Bergenia stracheyi, Bergenia ligulata And Bergenia ligulata etc. have many secondary metabolites such as 1. Bergenin 2. Tannic acid 3. Gallic acid 4. Stigmesterol 5. β-Sitosterol 6. catechin 7. (+)-Afzele...