Qi J, Yang P, Yi B, Huo Y, Chen M, Zhang J, Sun J. Heat shock protein 90 inhibition by 17-DMAG attenuates abdominal aortic aneurysm formation in mice. Am J Physiol Heart Circ Physiol 308: H841–H852, 2015. First published January 30, 2015; doi:10.1152/ajpheart.00470.2014.—Abdominal aortic aneurysm (AAA) is a common degenerative vascular disease whose pathogenesis is associated with activation of...

the basic pathogenic step in the process of tumor growth, invasion and metastasis is tumor-induced angiogenesis. the aim of this study was to evaluate the angiogenesis in colorectal carcinoma by microvascular density (mvd) determination with ihc (immunohistochemistry) method and to determine if and how angiogenesis correlates with clinicopathologic parameters. sixty two archival, paraffin embed...

objective(s): the goal of this study was assessing the prophylactic effect of exercise and its role as an adjuvant therapy on level of cytokines involved in angiogenesis in estrogen-dependent breast cancer. materials and methods: forty female balb/c mice were randomly assigned to exercise-tumor-exercise (ete), exercise-tumor-rest (etr), rest-tumor-exercise (rte) and rest-tumor-rest (rtr) groups...

angiogenesis, the process of new blood vessel formation from existing ones, plays an important role in  the physiologic circumstances such as embryonic development, placenta formation, and wound healing. it is also crucial to progress of pathogenic processes of a variety of disorders, including tumor growth and metastasis. in general, angiogenesis process is a multi-factorial and highly structu...

Today, adipokines are important cellular signaling proteins synthesized by adipose tissue and involved in a variety of processes, including inflammation, lipid glucose metabolism, insulin sensitivity, endothelial cell function, angiogenesis, blood pressure regulation, many others. This review examines the immunological endocrine function omentin its potential use as biomarker therapeutic target...

Although recent studies have suggested that CC chemokine CCL2 may directly affect the angiogenesis, the signaling events involved in such regulation remain to be determined. This study investigated a potential signal mechanism involved in CCL2-induced angiogenesis. Our in vitro and in vivo (hemangioma model of angiogenesis) experiments confirmed earlier findings that CCL2 can induce angiogenesi...

Branching morphogenesis, a specialized part of leads to the formation microstructures (tubes, canals, and glands), source active organ functions. The dynamic mechanisms involved are appearance/disappearance biomolecules morphogens gradients. In context angiogenesis, growth factors allow initiation, regulation, remodeling blood vessels. particular case micro-vascularization, it seems essential r...

Both 17 -estradiol (E2) and fibroblast growth factor-2 (FGF2) stimulate angiogenesis and endothelial cell migration and proliferation. The first goal of this study was to explore the potential link between this hormone and this growth factor. E2-stimulated angiogenesis in SC Matrigel plugs in Fgf2 / mice, but not in Fgf2 / mice. Cell cultures from subcutaneous Matrigel plugs demonstrated that E...