The 24-hour excretion of 17-ketosteroids and 17-hydroxycorticosteroids has been estimated in a series of male duodenal ulcer subjects and compared with that of 56 normal male controls. It has been found that both 17-ketosteroid and 17-hydroxycorticosteroid excretion is less in ulcer subjects than in the control group; these differences are not large but in the case of 17-hydroxycorticosteroids ...

In this issue of Blood, Hertlein and colleagues present compelling in vitro and in vivo evidence that the novel HSP90 inhibitor 17-DMAG is a potent and selective killer of CLL cells that mediates its effects through the targeted inhibition of NF-B. Their findings describe a promising new therapeutic approach for the treatment of this disease.

The use of tetramethylammonium hydroxide (T.M.A.H.) in place of potassium hydroxide in the Zimmermann reaction has been investigated. Although various pure steroids have different colour equivalents, a comparison of the results of 17-ketosteroid and 17-hydroxycorticosteroid estimations on a series of urines showed that the differences for the two reagents were only small and may be ignored. Tet...