For each of the 148 toxicants, EPA established a "benchmark" level that the agency considers safe. Eight of the 148 industrial poisons exceed EPA's benchmark safety levels all of the time in all 60,803 census tracts. All eight are carcinogens, that is, they are known to cause cancer: bis(2-ethylhexyl) phthalate; benzene; carbon tetrachloride; chloroform; ethylene dibromide; ethylene dichloride;...

Several studies have reported an association between -148 C/T polymorphism of Axis inhibition protein 2 (Axin2) and cancer risk; however, the results are inconsistent. In this study, a meta-analysis was performed to assess the association between -148 C/T polymorphism of Axin2 and susceptibility to cancer. Published case-control and cohort-based studies from PubMed, Embase, Wanfang, and CNKI we...

Recent studies have demonstrated that microRNA-148/152 family emerges as a attractive biomarker for predicting tumor prognosis and progression. However, outcomes of different studies are controversial. Eligible Literature were searched through online databases: PubMed, EMBASE and Web of Science. A total of 24 eligible studies were ultimately enrolled in this meta-analysis. Results indicated tha...

Associated to every knot or link in R (or in S) we can associate a group, called the fundamental group of the complement of the link, or more simply, the fundamental group of the link. A simple-minded way to approach this is to extend the idea of labeling a link diagram by group elements. Given a group G and an oriented link diagram D, we say that D can be labeled with G if we can label every a...

We consider the one-sided crossing minimization problem (CP): given a bipartite graph G and a permutation x 0 of the vertices on a layer, nd a permutation x 1 of the vertices on the other layer which minimizes the number of edge crossings in any straightline drawing of G where vertices are placed on two parallel lines and sorted according to x 0 and x 1. Solving CP represents a fundamental step...

naturally-occurring antimicrobial peptides provide a valuable tool for studying the role of different structural features in the activity of those peptides. A large array of derivatives based upon these structural models has been synthesized and studied in an attempt to increase the potency and selectivity of the native antimicrobial peptides. Enhancing the antimicrobial potency is often accomp...

1 Department of Molecular Genetics and Biochemistry, School of Medicine, Center for Computational Biology and Bioinformatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA 2 Department of Pharmacology, School of Medicine, University of Pittsburgh, and Language Technologies Institute, Institute for Software Research International School of Computer Science, Carnegie Mellon University, ...

Goodpasture antigen, the non-collagenous domain of α3 chain of type IV collagen [α3(IV)NC1], is the target antigen of anti-glomerular basement membrane (GBM) antibodies. The pathogenicity of T cell epitopes is not elucidated clearly. In this study, we aim to define the nephritogenic T cell epitopes and its critical amino acid residues. Twenty-four overlapping linear peptides were synthesized co...

Introduction.
 Sensitization to cow’s milk (CM) is one of the most common causes food allergy (FA) in young children; its clinical manifestations children are varied, since many organs and systems can be involved pathological process.
 The purpose: study profile IgE sensitization molecular components CM children, depending on phenotype disease.
 
 Materials Methods.
 Cl...