BACKGROUND Global tuberculosis (TB) control is encumbered by the lack of a rapid and simple detection method for diagnosis, especially in low-resource areas. An isothermal amplification method, hyperbranched rolling circle amplification (HRCA), was optimized to detect Mycobacterium tuberculosis (Mtb) in clinical sputum specimens. METHODS A clinical validation study was performed to assess the...

BACKGROUND Acute respiratory infections (ARIs) are the leading cause of children and their leading killer. ARIs are responsible for at least six percent of the world's disability and death. Viruses are one of the most common agents causing ARIs. Few studies on the viral etiology and clinical characteristics of ARIs have been performed in the northwest region of China, including Gansu Province. ...

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Pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136 (NSC 694501) selectively cross-links guanine residues located on opposite strands of DNA, and exhibits potent in vitro cytotoxicity. In addition, SJG-136 is highly active in vivo in hollow fiber assays. In the current investigation, SJG-136 was evaluated for in vivo efficacy in 10 tumor models selected on the basis of sensitivity of cells grown in...

PURPOSE This phase I study assessed the maximum tolerated dose (MTD), safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of SJG-136, a sequence-specific DNA cross-linking agent, in patients with advanced cancer. EXPERIMENTAL DESIGN In schedule A, seven patients received escalating doses of SJG-136 (6, 12, 24, and 48 μg/m(2)) daily for 5 of 21 days. Blood samples were colle...

Cucumis sativus L., which belongs to the Cucurbitaceae family, is cultivated worldwide as a vegetable crop. The fruit of C. sativus (cucumber) is used not only as food, but also in folk medicines and folk cosmetics. The leaves, stems and roots of C. sativus are reportedly used in Chinese folk medicine as antidiarrheal, detoxicant and antigonorrheal agents. However, these are not major uses, so ...

Cross-dehydrogenative coupling reactions between -ketoesters and electron-rich arenes, such as indoles, proceed with high regiochemical fidelity with a range of -ketoesters and indoles. The mechanism of the reaction between a prototypical ketoester, ethyl 2-oxocyclopentanonecarboxylate and N-methylindole, has been studied experimentally by monitoring the temporal course of the reaction by 1 ...

Mobile stations in high-tier Personal Communication Systems (PCS) are intended for high-mobility users and must thus operate in fast-changing environments. The first generation of high-tier PCS in North-America will be based on existing digital cellular standards including IS-I 36 TDMA. Moreover, dual-band receivers will be needed for extensive roaming. Adaptive equalizers were devised for IS-5...

BACKGROUND Chronic diarrhea (CD) is common in dogs, and information on frequency and distribution of primary and secondary causes is lacking. OBJECTIVES To evaluate underlying causes and predictors of outcome in dogs with CD. ANIMALS One hundred and thirty-six client-owned dogs with CD (≥3 weeks duration). METHODS Retrospective review of medical records (Small Animal Clinic, Freie Univers...