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The aim is to find the incidence of GDM using 75-g oral glucose tolerance test (OGTT) as a single-step screening and diagnosing GDM. Antenatal women attending Obstetrics department OP at Government Rajaji hospital, Madurai. Irrespective of age, parity and risk factors were subjected to a standardized 75 g oral glucose tolerance test (OGTT). Blood samples were obtained after 2 hours and venous p...
Hudson AE, Gollnick C, Gourdine JP, Prinz AA. Degradation of extracellular chondroitin sulfate delays recovery of network activity after perturbation. J Neurophysiol 114: 1346–1352, 2015. First published June 24, 2015; doi:10.1152/jn.00455.2015.—Chondroitin sulfate proteoglycans (CSPGs) are widely studied in vertebrate systems and are known to play a key role in development, plasticity, and reg...
BACKGROUND Various studies have shown a seasonal pattern in suicide in the developed societies; however, this pattern is not taken into consideration in most countries including Iran. OBJECTIVES The current paper studied the seasonal pattern of committing suicide in Northern Iran. MATERIALS AND METHODS The present study was a longitudinal study with time series features. Subject included su...
Apart from meningococcal disease in the sub-Saharan meningitis belt, the incidence and impact of life-threatening bacterial diseases in children across Africa have not been quantified. The clinical and epidemiological data on pneumococcal, Haemophilus influenzae type b (Hib), and other forms of bacterial meningitis, as well as data on other severe bacterial infections throughout the continent w...
To elucidate the genetic factors predisposing to AIDS progression, we analyzed a unique cohort of 275 human immunodeficiency virus (HIV) type 1-seropositive nonprogressor patients in relation to a control group of 1352 seronegative individuals in a genomewide association study (GWAS). The strongest association was obtained for HCP5 rs2395029 (P=6.79x10(-10); odds ratio, 3.47) and was possibly l...
Amyotrophic lateral sclerosis (ALS) is an adult-onset motor neuron disease that has been associated with a diverse array of genetic changes. Prominent among these are mutations in RNA-binding proteins (RBPs) or repeat expansions that give rise to toxic RNA species. RBPs are additionally central components of pathologic aggregates that constitute a disease hallmark, suggesting that dysregulation...
Inositol polyphosphate-5-phosphatase (INPP5D) was reported to be associated with Alzheimer's disease (AD) through modulating the inflammatory process and immune response. A recent genome-wide association study discovered a new locus single nucleotide polymorphism (SNP, rs35349669) of INPP5D which was significantly associated with susceptibility to late-onset Alzheimer's disease (LOAD) in Caucas...
Aggregation of the high-affinity IgE receptor induces the tyrosine phosphorylation of subunits of the receptor and the subsequent association with the receptor of the cytosolic protein tyrosine kinase Syk. The current experiments examined the functional importance of membrane association of Syk and the role of the SH2 domain in receptor-mediated signal transduction. Wild-type Syk and chimeric S...
References 1. Plebani M, Carraro P. Mistakes in a stat laboratory: types and frequency. Clin Chem 1997;43:1348–51. 2. Stuart J, Banfi G, Deom A, Narayanan S, Rabinovitch A. Major themes of the symposium. In: Proceedings of the second symposium: the impact of the pre-analytical phase of laboratory result. Oxford, UK: Becton Dickinson, 1996:5–9. 3. Hinckley CM. Defining the best quality-control s...
In this study, we isolated and sequenced a Helicobacter pylori gene, designated ftsH, coding for a 632-amino-acid protein which displayed striking similarity throughout its full length to FtsH proteins identified in Escherichia coli, Lactococcus lactis, and Bacillus subtilis. H. pylori FtsH also possessed approximately 200-amino-acid region containing a putative ATPase module which is conserved...
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