Being central players in thrombosis and hemostasis, platelets react in manifold and complex ways to extracellular stimuli. Cell-matrix and cell-cell interactions are mandatory for initial adhesion as well as for final development of stable plugs. Primary interfaces for interactions are plasma membrane proteins, of which many have been identified over the past decades in individual studies. Howe...

Ursino, M., C. A. Lodi, S. Rossi, and N. Stocchetti. Intracranial pressure dynamics in patients with acute brain damage. J. Appl. Physiol. 82(4): 1270–1282, 1997.—The time pattern of intracranial pressure (ICP) during pressurevolume index (PVI) tests was analyzed in 20 patients with severe acute brain damage by means of a simple mathematical model. In most cases, a satisfactory fitting between ...

Angiopoietin-1 (Ang1) exerts a vascular endothelial barrier protective effect by blocking the action of permeability-increasing mediators such as vascular endothelial growth factor (VEGF) through unclear mechanisms. Because VEGF may signal endothelial hyperpermeability through the phospholipase C (PLC)-IP3 pathway that activates extracellular Ca entry via the plasmalemmal store-operated channel...

This paper studies a machine (finite automaton) game for a two-player extensive-form stage game. We introduce a new measure ofstrategic complexity called “multiple complexity”, which considers in-formation structure inside the stage games as well as the number ofstates of machines. In contrast to Piccione and Rubinstein (1993),we prove existence of non-static equilibria....

BACKGROUND Apolipoprotein A-I (apoA-I), the major protein for high density lipoprotein, is essential for reverse cholesterol transport. Decreased serum levels of apoA-I have been reported to correlate with subcortical infarction and dementia, both of which are highly related to white matter lesions (WMLs). However, the association between apoA-I and WMLs has never been investigated. In this stu...

A set of 41 metal-ligand bond distances in 25 third-row transition-metal complexes, for which precise structural data are known in the gas phase, is used to assess optimized and zero-point averaged geometries obtained from DFT computations with various exchange-correlation functionals and basis sets. For a given functional (except LSDA) Stuttgart-type quasi-relativistic effective core potential...

A time-domain boundary condition is derived that accounts for the acoustic impedance of a thin boundary layer over an impedance boundary, based on the asymptotic frequency-domain boundary condition of Brambley [2011, AIAA J. 49(6), pp. 1272–1282]. A finite-difference reference implementation of this condition is presented and carefully validated against both an analytic solution and a discrete ...

In this work, ceramic hollow fiber supported polydimethylsiloxane (PDMS) composite membranes were developed by dip-coating PDMS layer on the surface of macroporous ceramic hollow fiber support. By controlling the properties of polymer solution and ceramic hollow fiber, high-quality ceramic hollow fiber supported PDMS composite membranes were fabricated for pervaporation (PV) recovery of biobuta...

A disintegrin and metalloproteinases (ADAMs) and matrix metalloproteinases (MMPs) are zinc metalloproteinases (ZMPs) that catalyze the "ectodomain shedding" of a range of cell surface proteins including signaling and adhesion molecules. These "sheddases" are associated with the invasion and metastasis of a range of cancers. Increased serum and tumor tissue levels of copper are also observed in ...

The Buddhist teacher Nichiren (1222–1282) has tended to be marginalized by many scholars of Buddhism as “intolerant” for his exclusivistic claim that only the Lotus Sðtra leads to salvation in the Final Dharma age (mappõ). While the Nichiren Buddhist tradition has often been aggressive in asserting its exclusive truth claim and in opposing other forms of Buddhism, the label of “intolerance” doe...