(123)I-meta-iodobenzylguanidine (MIBG) has become widely applied in Japan since its introduction to clinical cardiology and neurology practice in the 1990s. Neurological studies found decreased cardiac uptake of (123)I-MIBG in Lewy-body diseases including Parkinson's disease and dementia with Lewy bodies. Thus, cardiac MIBG uptake is now considered a biomarker of Lewy body diseases. Although sc...

The aim of this cohort study was to compare a condensed schedule of consolidation therapy with high-dose cytarabine on days 1, 2 and 3 (HDAC-123) with the HDAC schedule given on days 1, 3 and 5 (HDAC-135) as well as to evaluate the prophylactic use of pegfilgrastim after chemotherapy in younger patients with acute myeloid leukemia in first complete remission. One hundred and seventy-six patient...

BACKGROUND Recommendations on the use of I-123 metaiodobenzylguanidine (MIBG) scintigraphy in localising phaeochromocytomas vary. The accuracy of I-123 MIBG scintigraphy was determined by evaluating our own I-123 MIBG scans and performing a meta-analysis. MATERIALS AND METHODS Between January 1992 and May 2002, the I-123 MIBG scans of consecutive patients suspected of a phaeochromocytoma were...

Platinum rhodamine 123 |1'I(KU-I23)2] was synthesized in an effort to produce a new drug which would have the selective uptake into carcinoma cells of Rh-123 and the alkylating and radiosensitizing properties of the chloroplatinum moiety. Because both Rh-123 and ris-d ¡amminvdichloroplatinum(II) (CDDP) have been shown to become more cytotoxic at elevated temperatures, we tested the interaction...

Glucokinase (GK) plays a critical role for maintaining glucose homeostasis with regulating glucose uptake in liver and insulin secretion in pancreas. GK activators have been reported to decrease blood glucose levels in patients with type 2 diabetes mellitus. However, clinical development of GK activators has failed due to the loss of glucose-lowering effects and increased plasma triglyceride le...

The effects of Klebsiella pneumoniae endotoxin on the biliary excretion and renal handling of rhodamine-123 were investigated in rats at different times after intraperitoneal injection (1 mg/kg of body weight). The typical substrates for P glycoprotein, i.e., cyclosporine, colchicine, and erythromycin, inhibited the biliary clearance of rhodamine-123, whereas a substrate for organic cation tran...

The countable box product of ordinals is examined in the paper for normality and paracompactness. The continuum hypothesis is used to prove that the box product of countably many a-compact ordinals is paracompact and that the box product of another class of ordinals is normal. A third class trivially has a nonnormal product Because I have found a countable box product of ordinals useful in the ...

The December 1996 issue of Development, being a separate volume of the journal, is unusual in that it is entirely dedicated to developmental studies in the zebrafish (Danio rerio). It contains original research articles documenting the results of international research efforts to identify and functionally describe genes that regulate development in zebrafish. The majority of research contributi...

Nowadays Cloud Computing has gained in importance at a remarkable pace. The key characteristic of this technology is the possibility to provide new resources to the services in an elastic way according to current demand. In contrast to Cloud Computing, Multiagent Systems are focus on other features such as autonomy, decentralization, auto-organization, etc. This study demonstrates that this fea...

Isolates of Verticillium fungicola collected in 2002 in the Veracruz State, Mexico, and previously identified as V. fungicola var. fungicola, were compared to French isolates for genetic polymorphism and diversity in some physiological traits. Results were analysed based on studies of a larger group of European V. fungicola var. fungicola. RAPD analyses showed that Mexican isolates were genetic...