نتایج جستجو برای: 122

تعداد نتایج: 15685  

2016
Cuiping Wu Jinmei Zhang Xiangang Cao Qian Yang Dequan Xia

BACKGROUND Bile duct carcinoma is a common digestive tract tumor with high morbidity and mortality. As a kind of important non-coding RNA, microRNA (miR) plays an important role in post-transcriptional regulation. MiR-122 is the most abundant miR in the liver. Multiple studies have shown that miR-122 level is reduced in a variety of liver tumors and can be used as a specific marker for liver in...

Journal: :The EMBO Journal 2008
Jura Inga Henke Dagmar Goergen Junfeng Zheng Yutong Song Christian G Schüttler Carmen Fehr Christiane Jünemann Michael Niepmann

Hepatitis C virus (HCV) is a positive strand RNA virus that propagates primarily in the liver. We show here that the liver-specific microRNA-122 (miR-122), a member of a class of small cellular RNAs that mediate post-transcriptional gene regulation usually by repressing the translation of mRNAs through interaction with their 3'-untranslated regions (UTRs), stimulates the translation of HCV. Seq...

Journal: :Nature communications 2016
Shenyi Yin Yu Fan Hanshuo Zhang Zhihua Zhao Yang Hao Juan Li Changhong Sun Junyu Yang Zhenjun Yang Xiao Yang Jian Lu Jianzhong Jeff Xi

Downregulation of a predominantly hepatocyte-specific miR-122 is associated with human liver cancer metastasis, whereas miR-122-deficient mice display normal liver function. Here we show a functional conservation of miR-122 in the TGFβ pathway: miR-122 target site is present in the mouse but not human TGFβR1, whereas a noncanonical target site is present in the TGFβ1 5'UTR in humans and other p...

Objective(s): Impairment of nerve cells of brain induced by hypoxia results in energy-deprivation and dysfunction, which accompanies with neurons apoptosis. Improving function of nerve cells is important for treating cerebral anoxia. This study aimed to investigate the role of Quercetin (Quer) in hypoxia-induced injury of pheochromocytoma (PC-12) cells. Materials and Methods: PC-12 cells were c...

Journal: :Interactive CardioVascular and Thoracic Surgery 2013

Journal: :Neurologia medico-chirurgica 1965

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