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The grafting of human tumor cells into the brain of immunosuppressed mice is an established method for the study of brain cancers including glioblastoma (glioma) and medulloblastoma. The widely used stereotactic approach only allows for the injection of a single animal at a time, is labor intensive and requires highly specialized equipment. The guide screw method, initially developed by Lal e...
Johannes F.E. Mann, MD; Roland E. Schmieder, MD; Leanne Dyal, MSc; Matthew J. McQueen, MD; Helmut Schumacher, MD; Janice Pogue, PhD; Xingyu Wang, PhD; Jeffrey L. Probstfield, MD; Alvaro Avezum, MD, PhD; Ernesto Cardona-Munoz, PhD; Gilles R. Dagenais, MD; Rafael Diaz, MD; George Fodor, MD, PhD; Jean M. Maillon, MD; Lars Rydén, MD; Cheuk M. Yu, MD; Koon K. Teo, MD; and Salim Yusuf, DPh, MD, for t...
Abstract Background and objective: Hepatitis B virus (HBV) is a DNA virus with high tendency toward hepatic tissue. There are currently about 3 million HBV-infected people and 350 to 400 million chronic carriers of this virus in the world. X protein plays a role in the over-expression of oncogenes, carcinogenicity of liver cells and overlaps with the basal co...
Protest movements around the world have become increasingly likely to incite counterprotests that adopt an opposing stance. This study examines how a protest and counterprotest interact with shape each other as digitally networked connective action. My empirical focus is so-called Million MAGA March—in which supporters of U.S. President Donald Trump protested “stealing” November 2020 election b...
MBX-102/JNJ39659100 (MBX-102) is in clinical development as an oral glucose-lowering agent for the treatment of type 2 diabetes. MBX-102 is a nonthiazolidinedione (TZD) selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-gamma that is differentiated from the TZDs structurally, mechanistically, preclinically and clinically. In diabetic rodent models, MBX-102 has insuli...
damavand volcano with 5671 m height from sea level which covers 400 square km of area is the highest peak in the middle east. it is located at 50 km to the east of capital city of tehran, iran. it is in the fumarolic stage and exemplifies ongoing quaternary volcanic activity. damavan volcano was influenced by regional tectonics during its history. allenbach (1966) believed that the volcano orig...
Suzhou is one of China's most famous ancient cities. It is a city steeped in history with a rich ancient culture and is famous for its scenic spots, water canals, and its traditional Chinese rock and water gardens. With 35 km of waterways and rivers criss-crossing the city, it is often referred to as the "Venice of the East". Bordering Shanghai on the east, Wuxi City on the west, Zhejiang Provi...
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