OBJECTIVE Bisphosphonates may have a chondroprotective effect in patients with knee OA (KOA), but the results of clinical trials with oral bisphosphonates have been contradictory. In this Phase 2 randomized, partially blind clinical trial, we tested the efficacy of IA clodronate vs HA in patients with primary KOA. METHODS One hundred and fifty men or women aged 50-75 years suffering from KOA ...

We have combined the type Ia supernova (SNe Ia) data from the High-z SN Search and the Supernova Cosmology Project, and binned the combined data by flux-averaging in redshift intervals of ∆z = 0.05 and ∆z = 0.1. We find that the unbinned data yield a Hubble constant of H0 = 65 ± 1 km s−1 Mpc−1 (statistical error only), a matter density fraction of Ωm = 0.7 ± 0.4, and a vacuum energy density fra...

ABSTRACT- In order to produce transgenic rice lines lacking selectable marker gene, biolistic co-transformation technique using gold nanoparticles was adopted. In the first step, the efficiency of different sizes of gold particles was evaluated. The results showed that the efficiency of the nanoparticles in the transformation was comparable to that of the micro particles. Subsequently, two sepa...

Observations suggest that the properties of Type Ia supernovae (SNe Ia) may depend on environmental characteristics, such as morphology, metallicity, and age of host galaxies. The influence of these environmental properties on the resulting SNe Ia is studied in this paper. First it is shown that the carbon mass fraction X(C) in the C+O white dwarf SN Ia progenitors tends to be smaller for lower...

CONTEXT Cod liver oil supplements in infancy have been associated with a decreased risk of type 1 diabetes mellitus in a retrospective study. OBJECTIVE To examine whether intakes of omega-3 and omega-6 fatty acids are associated with the development of islet autoimmunity (IA) in children. DESIGN, SETTING, AND PARTICIPANTS A longitudinal, observational study, the Diabetes Autoimmunity Study ...

BACKGROUND Intracranial aneurysm (IA) is a socially important disease due to its high incidence in the general public and the severity of resultant subarachnoid hemorrhage that follows rupture. Despite the social importance of IA as a cause of subarachnoid hemorrhage, there is no medical treatment to prevent rupture, except for surgical procedures, because the mechanisms regulating IA formation...

OBJECTIVE To determine the recurrence risk of ictal asystole (IA) and its determining factors in people with epilepsy. METHODS We performed a systematic review of published cases with IA in 3 databases and additionally searched our local database for patients with multiple seizures simultaneously recorded with ECG and EEG and at least one IA. IA recurrence risk was estimated by including all ...

This article is a supplement to our 2006 ICIP paper, “Dead-End Elimination as a Heuristic for Min-Cut Image Segmentation” [1], which we assume the reader has read. We summarize the proof of the dead-end elimination theorem (due to Desmet et al. [2] and Goldstein [3]), briefly discuss the performance of our current implementation of DEE pairs, show the input images for which timings are referenc...

Six arctic foxes (Alopex lagopus) were marked with iophenoxic acid (IA), a substance which elevates concentrations of protein-bound iodine in blood plasma. Buccal absorption of IA was determined by placing 20 mg IA dissolved in 100% ethyl alcohol on the tongue. Blood samples collected from 1 to 36 wk following exposure showed that all foxes were marked already at 1 wk and continued until 13 wk;...

Isolated perfused segments of pig ileum and sigmoid colon were used as an extrinsically denervated model of intestinal fluid propulsion to compare the effects of intraluminal (IL) with intraarterial (IA) administration of cisapride and mebeverine. The ileal segments had a spontaneous mean activity of 0.008 (SEM 0.003) ml Krebs propelled aborally min-1, with propulsive waves at a mean frequency ...