also tested. 4-Nitroquinoline 1-oxide, 4-hydroxyaminoquinoline 1oxide, 3-methyl-4-nitropyridine 1-oxide, and 2,3-dimethyl-4nitropyridine 1-oxide caused wider growth-inhibiting zones with mutants of Escherichia coli, such as the DNA polymerase 1-deficient mutant, po/Al, and the recombination-deficient mutants, r<?cA13 and recB21, than with the wild strain. These compounds also caused wider growt...

also tested. 4-Nitroquinoline 1-oxide, 4-hydroxyaminoquinoline 1oxide, 3-methyl-4-nitropyridine 1-oxide, and 2,3-dimethyl-4nitropyridine 1-oxide caused wider growth-inhibiting zones with mutants of Escherichia coli, such as the DNA polymerase 1-deficient mutant, po/Al, and the recombination-deficient mutants, r<?cA13 and recB21, than with the wild strain. These compounds also caused wider growt...

a series of 1,4-dihydropyridine calcium channel blockers bearing 1-(4-x -benzyl)-5-imidazolyl substituent at 4 position (5a-e) (x=h, f) were synthesized and tested for antihypertensive activity in desoxycorticosterone acetate (doca)-induced hypertension in rats. amlodipine was used as the standard dihydropyridine. all compounds tested showed lower antihypertensive activity than that of amlodipi...