A halogenmethylsulfonyl moiety is incorporated in numerous active herbicides and fungicides. The synthesis of tribromomethyl phenyl sulfone derivatives as novel potential pesticides is reported. The title sulfone was obtained by following three different synthetic routes, starting from 4-chlorothiophenol or 4-halogenphenyl methyl sulfone. Products of its subsequent nitration were subjected to t...

A high-throughput screen of the NIH-MLSMR compound collection, along with a series of secondary assays to identify potential targets of hit compounds, previously identified a 1,3-diaminobenzene scaffold that targets protease-activated receptor 1 (PAR1). We now report additional structure-activity relationship (SAR) studies that delineate the requirements for activity at PAR1 and identify plasma...

Methylglyoxal (MGO) is a toxic, dicarbonyl metabolite in all living cells and its detoxification is regulated by glyoxalase I (GLOI). Herein, we rationally designed a precursor o-phenylenediamine-Phe-Phe-OH (1) which “click” reacts with MGO to yield amphiphilic methylquinoxaline-Phe-Phe-OH (2) to self-assemble into supramolecular hydrogel II (Gel II). Cryo-TEM images of Gel II suggested that th...

A new self-assembled and self-healing class of metal free, recyclable, heterogeneous Brønsted acid catalysts has been developed by the protonation aniline derivatives (tetrakis(4-aminophenyl)methane, leuco-crystal violet, benzidine, p-phenylenediamine) with aromatic sulfonic acids (tetrakis(phenyl-4-sulfonic acid)methane, 2,6-naphthalenedisulfonic acid). As a result, five three-dimensional crys...

It has been recently reported that catalytic quantities of crystalline catalase, in the presence of hydrogen peroxide, can rapidly oxidize a variety of molecules larger than hydrogen peroxide and aliphatic alcohols (1). The qualitative experiments have shown that oc-naphthol and p-phenylenediamine are condensed by oxidative coupling to indophenol purple; p-aminobenzoic acid, sulfathiazole, adre...

At the synapse, D-serine is an endogenous co-agonist for the N-methyl-D-aspartate receptor (NMDAR). It plays an important role in synaptic transmission and plasticity and has also been linked to several pathological diseases such as schizophrenia and Huntington's. The quantification of local changes in D-serine concentration is essential to further understanding these processes. We report herei...

Submitted: Jul 13, 2013; Accepted: Aug 26, 2013; Published: Aug 29, 2013 Abstract: Two new arylene diamines compounds have been synthesized via palladium-catalyzed reaction of 1,4-phenylenediamine with two aromatic dibromides. This one-pot reaction was based on using the catalyzed system resulting from Pd / BINAP, Pd / di-t-butylphosphinobiphenyl, Pd / P(t-Bu) , Pd / 1,3-bis(2,63 diisopropylphe...

In this study some new compounds have been prepared including thereaction of diazoium salt 1,4-phenylenediamine with 2-mercaptobenzaldehyde at (0-5)0C[F1]. Then Schiff bases [F2-F6] werethen synthesized through the reaction compound [F1] withsubstituteds aniline in absolute ethanol, and were convertedinto 2,3 - dihyroquinazolin 4(1H) one derivatives [F7-F11] by 2-amino benzoic acid ethanol. The...