Basal cell carcinoma (BCC) is driven by constitutive activation of the Hedgehog (Hh) signaling pathway, most commonly through loss-of-function mutations in PTCH1. Using animal models, we demonstrate here that microscopic BCC-like tumors initiated loss Ptch1 or gain Smo fail to progress and eventually enter into a dormant state. Because NOTCH1/2 TRP53 are detected human BCC, sought determine if ...

Le changement climatique (CC) concerne aussi bien notre mode de vie personnel que la manière dont nous envisageons l’avenir l’humanité. présent article étudie les citoyens norvégiens expriment linguistiquement leur motivation pour changer ou non afin réduire effets du CC. Il a point départ 1 077 réponses librement formulées à des questions d’enquête ouvertes. À travers une analyse semi-automati...

Scyphomedusae undergo a predictable ontogenetic transition from a conserved, universal larval form to a diverse array of adult morphologies. This transition entails a change in bell morphology from a highly discontinuous ephyral form, with deep clefts separating eight discrete lappets, to a continuous solid umbrella-like adult form. We used a combination of kinematic, modeling, and flow visuali...

470 Extracardiac endothelium patterns embryonic coronary arterio-venous connections JM. Perez-Pomares1; E. Cano2; R. Carmona1; A. Ruiz-Villalba3; A. Rojas4; Y-Y. Chau5; KD. Wagner6; N. Wagner6; ND. Hastie5; R. Munoz-Chapuli1 University of Málaga, Málaga, Spain; Max Delbruck Center for Molecular Medicine, Berlin, Germany; University of Navarra, Pamplona, Spain; Centro Andaluz de Biologı́a Molecul...

In this paper, the convergence of Zakharov-Kuznetsov (ZK) equation by homotopy analysis method (HAM) is investigated. A theorem is proved to guarantee the convergence of HAM and to find the series solution of this equation via a reliable algorithm. c ⃝ 2014 IAUCTB. All rights reserved.

Et Tu, Torsten? This critique of my Economic Policy paper generates many emotions. It is certainly an honor for my research to be taken seriously by such an eminent scholar as my friend Torsten Persson. And while any publicity is good, a negative citation dominates a positive one. There is irony; I came up with the original idea in a hallway conversation with Harry Flam a few feet from Persson’...

A traditional view of the nature of species holds that populations within species maintain genetic cohesion through substantial intraspecific gene flow and that the whole genome of a species is protected from interspecific gene flow by strong reproductive isolation. Both aspects of this view have been challenged. Reproductive barriers between recently evolved species can be incomplete and perme...

This paper describes and discusses the impacts of the passage of cold fronts on the vertical structure of the Carlos Botelho (Lobo-Broa) Reservoir as demonstrated by changes in physical, chemical, and biological variables. The data were obtained with a continuous system measuring 9 variables in vertical profiles in the deepest point of the reservoir (12 m) coupled with climatological informatio...