Mammalian homologues of two important yeast genes involved in DNA double-strand break repair and recombination, RAD51 and RAD54, have been isolated. Knock-out mutations of the genes in mice reveal both reassuring similarities to, and surprising differences from, the analogous mutant phenotypes in yeast.

1 Cardiac Imaging, University Heart Center, Zurich, Switzerland 2 Heart Lung Centrum, Leiden University Medical Center, Leiden, The Netherlands 3 Service de Cardiologie, C.H.U. De La Timone, Bd Jean Moulin, Marseille, France 4 Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Zurich, Switzerland CITATION: Cardiol Croat. 2016;11(7):238–251. | DOI: http://dx.doi.org/10....

Data from 3 summer feedlot studies were utilized to determine the environmental factors that influence heat stress in cattle and also to determine wind speed (WSPD; m.s(-1)) and solar radiation (RAD; W.m(-2)) adjustments to the temperature-humidity index (THI). Visual assessments of heat stress, based on panting scores (0 = no panting to 4 = severe panting), were collected from 1400 to 1700. Me...

To achieve specific and potent antitumor effect of hepatocyte carcinoma cells, replication defective adenoviral vectors, namely rAd/AFP-amiRG, rAd/AFP-amiRE and rAd/AFP-amiRP, were constructed which were armed with artificial microRNAs (amiRs) targeting essential functional genes glyceraldehyde-3-phosphate dehydrogenase, eukaryotic translation initiation factor 4E and DNA polymerase α respectiv...

BACKGROUND AND PURPOSE In acute ischemic stroke, white matter (WM) is considered more resistant to infarction than gray matter (GM). To test this hypothesis, we compared the fate of WM and GM voxels belonging to the acute diffusion-weighted imaging (DWI) lesion, expecting WM voxels to be more prone to reversal after thrombolysis. METHODS Reversible acute DWI (RAD) lesion was defined voxel-wis...

The mortality rate for patients with acute renal failure (ARF) remains unacceptably high. Although dialysis removes waste products and corrects fluid imbalance, it does not perform the absorptive, metabolic, endocrine, and immunologic functions of normal renal tubule cells. The renal tubule assist device (RAD) is composed of a conventional hemofilter lined by monolayers of renal cells. For test...

UNLABELLED (18)F-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ((18)F-FPEB) is a potent and specific radioligand for the metabotropic glutamate receptor subtype 5 (mGluR5). Before undertaking clinical research studies with (18)F-FPEB, we performed studies of human radiation dosimetry. METHODS Serial whole-body scans were obtained in 9 healthy human subjects (5 men, 4 women) for 190-440 min a...

All rings are commutative with 1 6= 0, and all modules are unital. The purpose of this paper is to investigate the concept of 2-absorbing primary submodules generalizing 2-absorbing primary ideals of rings. Let M be an R-module. A proper submodule N of an R-module M is called a 2-absorbing primary submodule of M if whenever a, b ∈ R and m ∈M and abm ∈ N , then am ∈M -rad(N) or bm ∈M -rad(N) or ...

Rapid Application Development (RAD) as a development methodology has its origins based within the commercial arena. As a result individual philosophies and perceptions of its rationale and applicability have led to considerable debate about its appropriateness for large complex Information Systems (IS) development. Even though RAD is becoming an increasingly accepted approach to IS development,...

Recombinant adenoviruses (RAd) and recombinant vaccinia viruses (RVV) expressing tumour-associated antigens (TAA) are used as anti-tumour vaccines. It is important that these vaccines deliver the TAA to dendritic cells (DC) for the induction of a strong immune response. Infection of myeloid DC (MDC) with RAd alone is relatively inefficient but CD40 retargeting significantly increases transducti...