background: gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. objective: the aim of this study is to understand characteristics of secondary electrons generated from interaction of gold nanoparticles gnps with x-rays as a function of nanoparticle size and beam energy and ...

Transient global cerebral ischemia (TGCI) induces by bilateral common carotid artery occlusion (BCCAO), and it mediates neuronal cell death of the CA1 hippocampal area. AM251 is a cannabinoid receptors type 1 (CB1) blocker that has been known to be protective against transient focal cerebral ischemia. JWH-015 is a selective agonist of CB2 and activator of CB1 that is involved in promotion of ne...

ONYX-015 has been reported to kill selectively tumor cells lacking functional p53. Genetic alterations of INK4a/ARF locus, which is a predominant event in malignant pleural mesothelioma, may result in loss of p14 and subsequent disruption of p53 pathway in cancer cells. In the present study, ONYX-015 was able to kill three mesothelioma cell lines (H28, H513, and 211H) with wild-type p53 but lac...

Prashant Sharma*, V M S R Murthy** Avinash Paul***& Ajoy Kr Singh*** *3 year Student, Bachelor of Technology in Mining Engineering, Indian School of Mines, Dhanbad826 015, India Contact No. +918092633969, +918871601404; Email: [email protected] **Professor, Mining Engineering Department, Indian School of Mines, Dhanbad826 015, India ***Scientist, Central Institute of Mining and Fuel...

Since use of antinociceptive chemical drugs for relief of pain have many side effects, medical plants seem very noticeable today. Previous findings indicate that Foeniculum vulgare (FV) modulates pain in both animal and human. The present work investigated the effects of Hydoalcoholic extract of FV on acute pain in Hot plate and Tail flick models. Albino mice (20-30 gr) were used for this study...

Since use of antinociceptive chemical drugs for relief of pain have many side effects, medical plants seem very noticeable today. Previous findings indicate that Foeniculum vulgare (FV) modulates pain in both animal and human. The present work investigated the effects of Hydoalcoholic extract of FV on acute pain in Hot plate and Tail flick models. Albino mice (20-30 gr) were used for this study...

ONYX-015 (dl1520) is an E1B 55-kilodalton protein-deficient replicating adenovirus that is currently in clinical trials as an antitumor agent. On the basis of the observation that the E1B 55kD gene product is able to bind to and inactivate p53, ONYX-015's mechanism of action is proposed to involve selective replication in and killing of p53-deficient cells. While its efficacy as a therapeutic a...

Pyramidal neurons in the rat hippocampus contain mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) to which the adrenal steroid corticosterone binds with differential affinity. We have used intracellular recording techniques to examine MR-mediated effects on membrane properties of CA1 pyramidal neurons in hippocampal slices from adrenalectomized rats. Low doses of corticoster...