Plant viruses are excellent tools for studying microbial-plant interactions as well as the complexities of host activities. Our study focuses on the role of C2 encoded by Beet severe curly top virus (BSCTV) in the virus-plant interaction. Using BSCTV C2 as bait in a yeast two-hybrid screen, a C2-interacting protein, S-adenosyl-methionine decarboxylase 1 (SAMDC1), was identified from an Arabidop...

In this retrospective study, cyclosporine levels at the second hour (C2 levels) were measured during oral cyclosporine intake in 28 pediatric hematopoietic stem cell transplant patients, and the relations between cyclosporine dosage and C0, C2 levels, C2/C0 ratio, and cyclosporine-related adverse effects were investigated. Cyclosporine levels at the second hour levels were found to be significa...

UNLABELLED The present study sought to validate the concept of C2 monitoring in 41 de-novo transplant patients treated with microemulsion of cyclosporine, mycophenolatesodium, steroids and basiliximab. RESULTS After 6 months patient and graft survival was 98%, rejection rate was 19%. In the first week only a few patients achieved the suggested C2 levels (19% > 1500, 50% > 1200 ng/ml) despite ...

C2-domains are widespread protein modules with diverse Ca2+-regulatory functions. Although multiple Ca2+ ions are known to bind at the tip of several C2-domains, the exact number of Ca2+-binding sites and their functional relevance are unknown. The first C2-domain of synaptotagmin I is believed to play a key role in neurotransmitter release via its Ca2+-dependent interactions with syntaxin and ...

Article history: Received 14 March 2013 Accepted after revision 3 July 2013 Available online 29 July 2013 Presented by Yves Meyer We consider the one-dimensional John–Nirenberg inequality: ∣∣{x ∈ I0: ∣∣ f (x)− f I0 ∣∣>α}∣∣ C1|I0|exp ( − C2 ‖ f ‖∗ α ) . A. Korenovskii found that the sharp C2 here is C2 = 2/e. It is shown in this paper that if C2 = 2/e, then the best possible C1 is C1 = 2 e4/e. ©...

Background: The C2 domain is a Ca2 sensor that drives the first step in the activation of conventional PKC isozymes. Results:Hydrophobic interactions drive membrane association and electrostatic interactions drive membrane retention of the C2 domain. Conclusion: The amplitude and location of conventional PKC signaling is controlled by residues in the C2 domain. Significance: Point mutations in ...

Photosynthetic electron flow in the bacterium Rhodopseudomonas sphaeroides involves two c-type cytochromes, one membrane-bound and the other a soluble protein, cytochrome c2. Membranes deficient in cytochrome c2 were used for photo-oxidation studies, with and without the addition of purified cytochrome c2. The results favour a series interrelation, membrane cytochrome c-cytochrome c2-reaction c...

Modeling and Simulation (M&S) technologies have matured suitably to provide real time tactical utility to warfighting Command and Control (C2) computer system users, but C2 systems adoption of M&S in their native applications has been slow for design, acceptance, computing and procurement reasons. While extensive work has been done with simulation based planning, execution monitoring, logistics...

Inappropriate use of endovenous ablation for varicose veins is a big issue many phlebological societies. Guidelines chronic venous disease recommend that symptomatic saphenous good indication ablation. However, the improvement quality life (QOL) after surgery patients with primary mild reflux, unclear. The purpose this prospective study was to identify QOL great vein (GSV) in reflux (MVR). We a...

We study a 2× 2 system of non-strictly hyperbolic conservation laws arising in three– component gas flooding for enhanced oil recovery. The system is not strictly hyperbolic. In fact, along a curve in the domain one family is linearly degenerate, and along two other curves the system is parabolic degenerate. We construct global solutions for the Riemann problem, utilizing the splitting property...