NATURE’S TRUTHS ARE FREQUENTLY difficult to discern, and they may run counter to preconceived notions. They may also be inconvenient, or even culturally offensive; think of the discovery that the earth revolves around the sun. Nevertheless, nature’s truths are immutable, whereas society’s conventions are not. Accordingly, scientists are expected to put convention aside as they weigh, in a compl...

The study of compliance with international agreements has gained momentum over the past few years. Since the conclusion of World War II, this research agenda had been marginalized by the predominance of realist approaches to the study of international relations. However, alternative perspectives have developed that suggest that international law and institutions are important influences on the ...

ASTHMA IS A COMPLEX DISEASE that has varied manifestations, is often difficult to treat, and indeed is even a challenge to define. Nevertheless, there are some features of asthma that are characteristic. Key among these is airways hyperresponsiveness (AHR), defined as an abnormally large mechanical response to challenge with a bronchial agonist such as acetylcholine. Exactly why asthmatic indiv...

We recently performed an updated network meta-analysis (NMA) to inform the British Association of Dermatologists guidelines for biologic therapy psoriasis (Smith et al., 2020Smith C.H. Yiu Z.Z. Bale T. Burden A.D. Coates L.C. Edwards W. al.British 2020 – a rapid update [e-pub ahead print].Br J Dermatol. 2020; 183: 628-637Crossref PubMed Scopus (39) Google Scholar). During this process, we ident...

The severity of clinical features and the outcomes in previous series of patients reported with Henoch-Schönlein purpura (HSP) vary greatly, probably due to selection bias. To establish the actual clinical spectrum of HSP in all age groups using an unselected and wide series of patients diagnosed at a single center, we performed a retrospective review of 417 patients classified as having HSP ac...

Women harbouring inactivating mutations in luteinizing hormone (LH) beta subunit ( LHB ) or LH receptor ( LHCGR ) genes have similar clinical manifestations characterized by female external genitalia, spontaneous breast and pubic hair development at puberty, and normal or late menarche followed by oligo-amenorrhea and infertility. Oestradiol and progesterone levels are normal for the early to m...

The available evidence for long-term, low-dose treatment with 14and 15-membered ring macrolides in non-cystic fibrosis (CF) bronchiectasis, COPD, chronic sinusitis, and asthma is reviewed with special attention to possible adverse effects and the emergence of resistance during long-term macrolide treatment. Macrolide maintenance therapy has been proven to be of benefit in diffuse panbronchiolit...

The available evidence for long-term, low-dose treatment with 14and 15-membered ring macrolides in non-cystic fibrosis (CF) bronchiectasis, COPD, chronic sinusitis, and asthma is reviewed with special attention to possible adverse effects and the emergence of resistance during long-term macrolide treatment. Macrolide maintenance therapy has been proven to be of benefit in diffuse panbronchiolit...

ABSTRAK Penelitian ini bertujuan untuk memetakan penelitian-penelitian sebelumnya tentang audit syariah dan perannya dalam meningkatkan kepatuhan di lembaga keuangan (LKS). juga menguraikan tantangan yang dihadapi oleh LKS solusi mengimplementasikan syariah. Sebanyak 308 publikasi diperoleh dari database Google scholar, Emerald Insight, Research Gate, Crossref, Microsoft Academic and Pubmed dia...

A BGK-type model for a reactive multicomponent gas undergoing chemical bimolecular reactions is here presented. The mathematical and physical consistency of the model is stated in detail. The relaxation process towards local Maxwellians, depending on mass and numerical densities of each species, as well as on common mean velocity and temperature, is investigated with respect to chemical equilib...