Mapping arrhythmias and concretely atrial fibrillation (AF) is complicated by our inability to determine local from far field electrograms, as interfere with the identification of activity in specific electrode location. In particular, how “local” on any catheter not yet biophysically defined. We tested hypothesis that EGM conformation configurations can be explained modelling biophysical relat...

After early microbicide candidates failed in clinical trials to prevent HIV, recent news from the South African CAPRISA-004 study suggest that the new generation of vaginal microbicide gels using antiretroviral drugs like tenofovir could be effective and reduce HIV and herpes simplex virus (HSV)-2 acquisition.1 This landmark study greatly energized the field and revived enthusiasm for the devel...

Abstract Aim Immunosuppressive medication might increase the likelihood of wound morbidity, with possible higher rate surgical site infections (SSIs). We aim to identify short-term outcomes and hospital stay after incisional hernia repair transversus abdominis release (TAR) in patients versus without immunosuppression. Material & Methods All undergoing open abdominal wall uni-or bilateral T...

Introduction Monosodium urate (MSU) crystal induced interleukin-1 (IL-1b) secretion is a critical pathogenic factor in the development of gout and serves as therapeutic target in these patients. Nevertheless, without co-stimulation by a pro-IL-1ß inducing factor, e.g. lipopolysaccharides (LPS), MSU alone cannot induce IL-1b secretion in vitro. The endogenous Toll-like receptor 4 (TLR-4) agonist...

Methods All FMF, TRAPS, MKD and CAPS patients enrolled in the Eurofever registry until March 2013 were evaluated. For each disease gold standards were considered according to the following criteria: i) clinical validation by centers and disease-principal investigator, ii) confirmative molecular analysis (2 mutations for MEFV with at least one mutation in exon 10, 2 mutations of MVK gene, 1 muta...