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BACKGROUND Nefopam, a non-opiate analgesic, has been regarded as a substance that reduces the requirement for morphine, but conflicting results have also been reported. The inhibition of monoamine reuptake is a mechanism of action for the analgesia of nefopam. The spinal cord is an important site for the action of monoamines however, the antinociceptive effect of intrathecal nefopam was not cle...
In this work, the structural and magnetic properties of LaMn1-xCoxO3 (x = 0.00, 0.25, 0.50, 0.75, 1.00) are investigated. The structural characterization of compounds by X-ray powder diffraction is evidence for a rhombohedral structure (R -3c space group). Much less increase of the unit cell volume suggests that Co enters in lattice as Co+2 for x ≤ 0.5 while much more decrease of the unit cell ...
Anti-inflammatory effects of acetonic and methanolic extracts of aerial parts of Stachys byzanthina were investigated in this study. For assessment of anti-inflammatory properties, two well-characterized inflammatory models, formalin test and carrageenan-induced paw edema were used. In the former, the recording of the early phase started immediately after formalin injection and lasted for 10 mi...
During the development of obesity, adipose tissue undergoes major expansion and remodeling, but the biological processes involved in this transition are not well understood. The objective of this study was to analyze global gene expression profiles of adipose tissue in dogs, fed a high-fat diet, during the transition from a lean to obese phenotype. Nine female beagles (4.09 ± 0.64 yr; 8.48 ± 0....
BACKGROUND To date, putative prognostic biomarkers have shown limited utility from the clinical perspective for bladder urothelial carcinoma. Herein, the expression of beta-tubulin-3 and c-Myc was evaluated to determine their prognostic potential. METHODS In formalin fixed-paraffin embedded blocks, immunohistochemical expression of c-Myc and beta-tubulin-3 was evaluated. H score ranging from ...
Introduction: Orexin-A and B (Hypocretin 1 and 2) are neuropeptides that are mostly expressed in the posterior and lateral hypothalamus (LH). Intracisternal (ICV) and intratechal (IT) injections of orexin-A (hypocretin-1) have been shown to elicit analgesic responses in formalin test. However, the locations of central sites that may mediate these effects have not been clearly elucidated. Ore...
Characterization of Nociceptive Behaviors Induced by Formalin in the Glabrous and Hairy Skin of Rats
INTRODUCTION Glabrous skin and hairy skin are innervated by different types of noxious fibers. However, the different nociceptive behaviors induced by formalin, a commonly used model of acute inflammatory pain, have not yet been systematically examined in the glabrous and hairy skin. METHODS In this study, we compared nociceptive behaviors induced by formalin injections (2%, 4%, and 8%) into ...
Cumi – cumi adalah salah satu hasil laut yang mengandung tinggi protein dan menjadi makanan biasa dikonsumsi oleh masyarakat. Protein pada dapat mempercepat proses pembusukan. Formalin digunakan untuk memperpanjang umur penyimpanan cumi. merupakan bahan dilarang penggunaannya dalam menurut Peraturan Menteri Kesehatan Nomor 033 Tahun 2012 Tentang Bahan Tambahan Pangan. Penelitian ini bertujuan m...
هدف پژوهش حاضر، تعیین میزان آشنایی و استفادة کتابداران کتابخانههای دانشگاهی همدان از امکانات و قابلیتهای وب 0/2 است. پژوهش حاضر از نوع کاربردی و به روش پیمایشی و با رویکرد توصیفی انجام شده است.جامعه آماری این پژوهش، شامل کتابداران کتابخانههای دانشگاهی، دانشکدهای و مؤسسههای آموزش عالی همدان (47 نفر) میباشد. ابزار مورد استفاده برای گردآوری دادهها، پرسشنامه محققساخت...
هدف: ظهور تجارت اجتماعی و فناوریهای وب 0/2 بهخصوص رسانههای اجتماعی، شکل جمعآوری اطلاعات و نحوه کسب هوشمندی رقابتی را تغییر داده است. هوشمندی کسبشده از این محیط باعث شد مفهوم جدیدی بهنام هوشمندی رقابتی 0/2 پدیدار شود که نحوه کسب آن از جهات بسیاری با نوع قبلی آن تفاوت دارد. هدف این پژوهش طراحی چارچوبی برای کسب این نوع هوشمندی، بر مبنای استفاده از ابزارهای فناوری وب 0/2 و بهطور خاص رسانهها...
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