Dieser Beitrag präsentiert ein webbasiertes Serious Game, das Studierenden in medizinischen Studiengängen die Möglichkeit gibt, Arzt-PatientenGespräche in Form von Rollenspielen mit simulierten Patienten selbständig und systematisch zu trainieren. Der Phase der Immersion (Rollenspiel) folgt dabei eine Phase der distanzierten Reflexion, um den lernförderlichen Perspektivenwechsel zu unterstützen...

objective: cardiac cell differentiation with the help of mirnas has recently opened a promising window for the restoration of myocardial infarction. independent mir-1-2/133a-1 and mir-206/133b clusters are known to be expressed in cardiac and skeletal muscles, respectively. mir-133b differs from mir-133a by only one nucleotide. the sequence similarity of these two mirnas suggests that they targ...

Background: Colorectal and breast carcinoma are frequently diagnosed cancers. At advanced stages, cancers metastasize to certain organs resulting in loss of function these organs, eventually death. Therefore, there is a specific need for the prognosis Currently, microRNAs (miRNAs), have emerged as new target cancer-specific biomarker. Objective: To examine expression miRNA primary metastatic co...

Introduction Polychlorinated biphenyls (PCBs), organic lipophilic pollutants that accumulate through diet and increase with age, have been associated polycystic ovary syndrome (PCOS) shown to affect microRNA (miRNA) expression. This work aimed determine if PCBs were circulating miRNAs whether there any correlations serum PCB/miRNA levels hormonal changes. Methods 29 non-obese PCOS healthy contr...

in the recent years deregulation for micrornas expression pattern have emerged as a possible molecular factor for carcinogenesis. it has been reported that the expression of mir-9 was down-regulated in human gastric adenocarcinoma. to figure out the molecular mechanism of this down regulation, the methylation status in promoters of mir-9 family loci were compared in the human gastric adenocarci...

Abstract Background Pericoronary adipose tissue (PCAT) plays a key role in the pathogenesis of atherosclerosis. PCAT is source microRNAs (miRs) that acts as messengers for intercellular communication. In this study, we investigated whether surrounding coronary occlusive atherosclerotic lesions shows specific miR expression patterns compared to plaque-free segments. Purpose To evaluate miRs are ...

Objective(s): Chronic myelogenous leukemia (CML) is a chronic myeloproliferative disorder characterized by the accumulation of myeloid cells with a chromosomal translocation known as the Philadelphia chromosome. In this study, we investigated the roles of miR-570 in CML development. Materials and Methods: Expression of miR-570 in CML samples and cell lines was determined by qRT-PCR. Glucose upt...

MicroRNAs are non-coding RNAs. Studies have shown that miRNAs are expressed aberrantly in stroke. MiR-1 enhances ischemic damage, and previous study has demonstrated that reduction of miR-1 level has neuroprotective effect on Middle Cerebral Artery Occlusion(MCAO). Since apoptosis is one of the important process in neural protection, possible effect of miR-1 on this pathway has been tested in t...

Abstract Objective To investigate lncRNAs and their roles in regulating the pulmonary inflammatory response under dexamethasone (Dex) treatment. Methods IL-1? (10 ng/mL) LPS (1 ?g/mL) was used to construct cell models with A549 cells; performed better against LPS. Different concentrations of Dex were attenuate inflammation induced by IL-1?, its effect assessed via RT-PCR detect cytokine-related...

micrornas are highly conserved small non-coding regulatory rnas that involve in post transcriptional regulating of gene expression during different cellular mechanisms. aberration of mir-218 expression during tumorigenesis of different solid tumors has been reported by numerous studies. in current systematic review article, by using the terms “mir-218” and “cancer” we first searched for english...