O equilíbrio ambiental pode ser avaliado observando as características do ambiente, e da população de grupos organismos específicos, considerados bioindicadores. Assim, o objetivo desse trabalho é avaliar a fauna edáfica serrapilheira em dois fragmentos florestais na Amazônia Meridional, analisando sua utilização como potenciais Foram realizadas análises um fragmento florestal (A1) uma área rec...

Objective: Free-living amoeba (FLA) are protozoa living in soil and natural man-made water systems. They attract much attention owing to the illnesses associated with them their relationships bacteria. In this study, effect of cell-free supernatant (CFS) obtained from FLA against Staphylococcus was investigated. Materials Methods: Environmental strains (A1, A2, A3) were lake swimming pools Ista...

Heterocyclic compounds are vital in rational drug design by providing convenient means for the optimization of drugs or candidates. Isoxazolidine (a heterocyclic compound) derived from (3 + 2) cycloaddition reaction is reported to possess anticancer, antiviral, antibacterial, and anti-inflammatory properties. The mechanistic study chemo-, regio-, stereo-selectivities (32CA) diarylnitrones (A1) ...

The majority of phospholipase A2 activity in myocardium is calcium-independent and selective for hydrolysis of plasmalogen substrate (Wolf, R. A., and Gross, R. W. (1985) J. Biol. Chem. 260, 7295-7303; Hazen, S. L., Stuppy, R. J., and Gross, R. W. (1990) J. Biol. Chem. 265, 10622-10630). Accordingly, identification of an inhibitor which selectively targets calcium-independent phospholipases A2 ...

Cholera enterotoxin (CT) is produced by Vibrio cholerae and excreted into the culture medium as an extracellular protein. CT consists of one A polypeptide and five B polypeptides associated by noncovalent bonds, and CT-B interacts with CT-A primarily via the A2 domain. Treatment of CT with trypsin cleaves CT-A into A1 and A2 fragments that are linked by a disulfide bond. CT-B binds to gangliosi...

Introduction: We wished to compare the survival benefit associated with gross total resection (GTR) in World Health Organization (WHO) grade II astrocytomas (A2) to those of grade III (A3) and grade IV (glioblastoma) astrocytomas. Methods: Using the Surveillance, Epidemiology, and End Results (SEER) Program (1999-2010) database, we identified 4,113 A2 patients. Surgical resection was defined as...

AIMS To examine the potential role of the lipolytic enzyme phospholipase A2, produced by Helicobacter pylori in ulcer formation. METHODS Phospholipase A2 activity in H pylori was compared with that in 10 commonly occurring pathogenic bacteria. Phospholipase A2 activity and its cytotoxic metabolite, lysolecithin, in the basal gastric aspirates of 12 patients infected with H pylori were compare...

Introduction: Breast cancer is the second most common cancer in the world and the most common cancer in Iranian women in terms of rate. The cytochrome P-450c17α (CYP17) gene, located on chromosome 10q24.3, encodes the enzyme cytochrome P-450c17α, which functions as a susceptibility factor in breast cancer. Material and methods: Three common polymorphisms have been described in the CYP17 gene. T...