Nitration of protein tyrosine residues by nitric oxide (NO)-derived reactive species results in the production of stable nitrotyrosine (NT) moieties that are immunochemically detectable in many regions of normal brain and enriched in those areas containing constitutive nitric oxide synthase (cNOS). These include the caudate-putamen nucleus (CPN) and the globus pallidus, which receives major inh...

The mammalian neocortex is parcellated into anatomically and functionally distinct areas. The establishment of area-specific neuronal diversity and circuit connectivity enables distinct neocortical regions to control diverse and specialized functional outputs, yet underlying molecular controls remain largely unknown. Here, we identify a central role for the transcriptional regulator Lim-only 4 ...

Repair of specific neuronal circuitry in the neocortex may be possible via neural precursor transplantation or manipulation of endogenous precursors in situ. These approaches will almost certainly require a detailed understanding of the mechanisms that control survival and differentiation of specific neuronal lineages. Such analysis has been hampered by the overwhelming diversity of neuronal ty...

Abstract Background Isolated common peroneal neuropathy (CPN) is the most lower extremity mononeuropathy and third overall in adults. It often associated with multiple aetiologies, such as trauma, hereditary neuropathies iatrogenic causes. We report a rare case of acute bilateral foot drop late adolescent female following rapid weight loss attributable to intermittent fasting diet. Case present...

We present an interdisciplinary approach that, by incorporating a range of experimental and computational techniques, allows the identification and characterization of functional/immunogenic domains. This approach has been applied to ArtJ, an arginine-binding protein whose orthologs in Chlamydiae trachomatis (CT ArtJ) and pneumoniae (CPn ArtJ) are shown to have different immunogenic properties ...

We describe in this paper a general method for automatic code generation from Coloured Petri Nets (CP-nets or CPN). The method is supported by the Design/CPN tool which has been extended during the past few years, such that it also can be used to generate code automatically from a CPN model. We do not describe the algorithms for code generation but rather the context such a tool is used in. The...

The genetic code is the triplet code based on the three-letter codons, which determines the specific amino acid sequences in proteins synthesis. Choosing an appropriate model for processing these codons is a useful method to study genetic processes in Molecular Biology. As an effective modeling tool of discrete event dynamic systems (DEDS), colored petri net (CPN) has been used for modeling sev...

This paper presents a methodology to automatically generate motion commands for the slave robot in the framework of a discrete-event-based teleprogramming system. The teleprogramming system basically requires the geometric model of the work-piece and the constraint environment, and additionally the CPN (Controlled Petri Net) model of the contact state transitions. In order to simplify the model...

The potential role of Chlamydia pneumoniae (Cpn) in atherosclerosis has attracted considerable attention. On the basis of early encouraging results, it was anticipated that infection with Cpn might prove a novel treatable risk factor for atherosclerosis, with a relevance comparable to that of Helicobacter pylori in peptic ulcer disease. The effect of antibiotic treatment on clinical outcome bec...

Ceruloplasmin (CPN) concentrations were measured by p-phenylenediamine oxidase assay in serums from (a) 30 control Fischer rats; (b) 5 rats with primary sarcomas induced by i.m. injection of nickel subsulfide (alpha Ni3S2), and (c) 12 rats at intervals up to six weeks after s.c. transplantation of four alpha Ni3S2-induced sarcomas. Serum CPN concentrations were not significantly increased in ra...