Splicing factors of the SR protein family share a modular structure consisting of one or two RNA recognition motifs (RRMs) and a C-terminal RS domain rich in arginine and serine residues. The RS domain, which is extensively phosphorylated, promotes protein-protein interactions and directs subcellular localization and-in certain situations-nucleocytoplasmic shuttling of individual SR proteins. W...

The 21-gene Recurrence Score (RS) assay (Oncotype DX) predicts the risk of recurrence and benefit from chemotherapy in estrogen receptor (ER) positive, Her-2/neu negative, node negative and, more recently, limited nodepositive (<3) breast cancer. The 21-gene RS is divided into low, intermediate and high risk groups corresponding to a likelihood of recurrence within 10 years of initial diagnosis...

OBJECTIVE Concussed athlete evaluations often include symptoms, balance, and neurocognitive assessments. We sought to identify the relationship between subjective symptom reports and objective clinical measures. DESIGN A retrospective assessment. SETTING A research laboratory. PATIENTS Concussed collegiate-level athletes (N = 32, 19.7 years) evaluated pre- and postinjury (less than 48 hou...

SR proteins constitute a widely conserved family of splicing regulators. Negative autoregulation of SR proteins has been proposed to exert homeostatic control on the splicing environment, but few examples have been studied and the role of isoforms that lack the RS domain is unclear. We show that genes Rbp1 and Rbp1-like, which encode Drosophila homologs of mammalian SRp20, negatively autoregula...

PURPOSE To explore patient demographics and motivations in choosing refractive surgery (RS) or contact lenses (CL) and factors influencing their choice of practice. METHODS A questionnaire was presented to 212 RS and 115 CL patients at four RS centres and three CL centres, respectively. The authors, with consent from the clinics and patients, collected all data. No patient or clinic refused t...

Background and Aims: Wild-type RS-12 strain of mumps virus has been isolated from an Iranian patient and has been attenuated after several serial passages. This study was designed to determine nucleotide and amino acid substitutions in the HN, F and SH genes during attenuation of the wild-type virus. Materials and Methods: Required viral samples prepared at Razi Vaccine and Serum Institute. Vi...