It is suggested that previous data indicate 3 major epidemics of kala-azar in Assam between 1875 and 1950, with inter-epidemic periods of 30-45 and 20 years. This deviates from the popular view of regular cycles with a 10-20 year period. A deterministic mathematical model of kala-azar is used to find the simplest explanation for the timing of the 3 epidemics, paying particular attention to the ...

Objectives: A rapid immunochromatographic dipstick test (ICT) has become available for the qualitative detection of anti-Leishmania antibody using recombinant rK39 antigen. This study was carried out at the department of Microbiology of Rajshahi Medical College, Bangladesh, in order to evaluate the diagnostic potential of immunochromatographic dipstick test. Methodology: A total of one hundred ...

severe toxic reactions and, as such, small children, corpulent subjects and patients suffering from general anasarca, not an uncommon condition associated with kala-azar, could not be treated with urea stibamine. At the Annual General Meeting of the Assam and Northern Bengal Branch of the British Medical Association that was held in Shillong in November 1943, Shortt read an interesting paper de...

© 2018 Indian Dermatology Online Journal | Published by Wolters Kluwer Medknow Post Kala‐azar dermal leishmaniasis (PKDL) is a late cutaneous manifestation of untreated or partially treated visceral leishmaniasis (VL) and is caused by the same organism, i.e., Leishmania donovani. It characteristically manifests as macules, nodules, plaques, and facial erythema. A 19‐year‐old male presented with...

In the 19(th) century, a devastating epidemic of visceral leishmaniasis (kala-azar) swept through northeast India. After identification of the pathogenic agent, Leishmania donovani, in 1903, the question of its transmission remained to be resolved. In 1904, thanks to work by L. Rogers on cultures of this parasite it became probable that a haematophagous arthropod was responsible for transmissio...

Sir, Post kala-azar dermal leishmaniasis (PKDL) is a wellrecognized sequel of kala-azar in India, developing in approximately 20% cases after a variable time interval of 1 – 5 years (1). The disease occurs chiefly in the eastern parts of India, an area that also has a high prevalence of leprosy. PKDL manifests as symmetrically distributed hypopigmented macules, papules, infiltrated plaques and ...

Using a randomized study, we compared a daily and an alternate-day regimen of amphotericin B for the treatment of kala-azar, with respect to efficacy, adverse reactions, cost-effectiveness, and tolerance. The study subjects were 80 kala-azar patients, drawn from the first four decades of life and matched by age, sex, and parasite load. The patients were randomly allocated to treatment groups A ...

The diagnosis of visceral leishmaniasis (kala-azar) remains difficult in rural endemic areas and practical and reliable tests are badly needed. Two serological tests, the Direct Agglutination Test (DAT) and an rK39-antigen-based dipstick test, were compared to parasitological diagnosis in a group of 184 patients presenting at a tertiary care centre in south-eastern Nepal with a history of fever...