Visual Place Recognition (VPR) approaches have typically attempted to match places by identifying visual cues, image regions or landmarks that high “utility” in a specific place. But this concept of utility is not singular - rather it can take range forms. In letter, we present novel approach deduce two key types for VPR: the cues `specific' an environment, and particular We employ contrastive ...

Five to ten percent of HIV-1 infected individuals remain asymptomatic up to a year after infection. This type of infection is known as a long-term non-progressive (LTNP) infection, and can be characterized as a viral phenotype with a lack of CD4+ Tcell death. This MQP deals specifically with a group of LTNPs known as the French ALT group who have a form of the virus that is considerably less cy...

The enhanced radar return associated with melting snow, ‘the bright band’, can lead to large overestimates of rain rates. Most correction schemes rely on fitting the radar observations to a vertical profile of reflectivity (VPR) which includes the bright band enhancement. Observations show that the VPR is very variable in space and time; large enhancements occur for melting snow, but none for t...

A number of approaches for Cas9-mediated transcriptional activation have recently been developed, allowing target genes to be overexpressed from their endogenous genomic loci. However, these approaches have thus far been limited to cell culture, and this technique has not been demonstrated in vivo in any animal. The technique involving the fewest separate components, and therefore the most amen...

and colleagues. The holes allow the mixing of proteins that are usually exclusively nuclear or cytoplasmic. The damage, the mixing, or both may cause a G2 cell cycle arrest that allows the virus to replicate more efficiently. For some time Greene has been studying the ability of Vpr to arrest the cell cycle. Vpr shuttles into the nucleus, so Greene suspected that it could affect the shuttling o...

The targeting of HIV-1 using antibodies is of high interest as molecular tools to better understand the biology of the virus or as a first step toward the design of new inhibitors targeting critical viral intracellular proteins. Small and highly stable llama-derived single-domain antibodies can often be functionally expressed as intracellular antibodies in the cytoplasm of eukaryotic cells. Usi...

A number of approaches for Cas9-mediated transcriptional activation have recently been developed, allowing target genes to be over-expressed from their endogenous genomic loci. However, these approaches have thus far been limited to cell culture, and this technique has not been demonstrated in vivo in any animal. The technique involving the fewest separate components, and therefore most amenabl...

A lentivirus-based packaging system was designed to reduce the chance of recombination between helper and gene transfer vector sequences by using the constitutive transport element (CTE) derived from Mason-Pfizer monkey virus for expression of the viral proteins and the Rev-Rev response element (RRE) combination for expression of the gene transfer vector. Using this approach, we evaluated a ser...

UNLABELLED CodY is a global transcriptional regulator in low-G+C Gram-positive bacteria that is responsive to GTP and branched-chain amino acids. By interacting with its two cofactors, it is able to sense the nutritional and energetic status of the cell and respond by regulating expression of adaptive genetic programs. In Bacillus subtilis, more than 200 genes, including those for peptide trans...